You searched for: Y-27632 dihydrochloride

Supplier: Enzo Life Sciences

ROCK inhibitor

Supplier: MilliporeSigma

A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688000) in H₂O.

Supplier: BIOGEMS INTERNATIONAL INC.

Y-27632 is a selective inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases that selectively competes with ATP for binding to the catalytic site. It is reported to diminish dissociation-induced apoptosis, increase cloning efficiency, and facilitate subcloning after gene transfer in human embryonic stem cells (hES).

Supplier: MilliporeSigma

A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases.

Supplier: Ambeed

Y-27632 dihydrochloride 99%

Supplier: Adipogen

Potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor. Tumor cell invasion and metastasis suppressor. Smooth muscle relaxant. Decreases liver fibrosis by hepatic stellate cell growth inhibition. Antinociceptive. Blocks generation of inflammatory cytokines. Stem cell research modulator. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated human embryonic stem (hES) cells without affecting their pluripotency. Increases survival rate of hES cells undergoing cryopreservation.

Supplier: Selleck Chemicals

Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with K_i of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.