Hypericin

Supplier: Abcam

Selective PKC inhibitor (IC₅₀ = 3.3 μM). Antiviral agent. Potent tyrosine kinase inhibitor (IC₅₀ = 7.5 μM). Potent CKII inhibitor (IC₅₀ = 6 nM). Inactivates enveloped viruses including HIV. Promotes VEGF and TGF-β production. Shows photosensitizing and antidepressant effects in vivo. .

Supplier: Thermo Scientific Chemicals

Inhibitor of protein kinase C; induces photosynthesized apoptosis

Supplier: Enzo Life Sciences

PKC inhibitor

Supplier: BeanTown Chemical

CAS: 548-04-9; EC No: 208-941-0; MDL No: MFCD00016683 Powder; Molecular Formula: C30H16O8; MW: 504.44

Supplier: G-Biosciences

Natural product found in St. John’s Wort (Hypericum perforatum). A multifunctional agent that has been reported to be antidepressive, antineoplastic, antitumor and antiviral. Inhibitory effects have been demonstrated on various enzyme including MAO, PKC, dopamine-ß-hydroxylase, reverse transcriptase, telomerase and CYP.1 Hypericin can cause photosensitivity – as a result, it is being investigated as an agent in photodynamic therapy.

Supplier: Ambeed

Hypericin ≥98%

Supplier: Adipogen

One of the principal active constituents of St. John's Wort (Hypericum perforatum). Hypericin is a photosensitive pigment/chromophore with bright red fluorescence emission (lambdamax: 594nm). Has a high triplet quantum yield and ability to produce considerable amounts of singlet oxygen and other ROS species when photoactivated. Antiviral, anticancer and antidepressant agent. Inactivates enveloped viruses (including HIV). This photosensitizing agent has shown to induce apoptosis and necrosis in cancer cells during photodynamic therapy. Selective inhibitor of protein kinase C (PKC). Has been shown to inhibit other kinases and targets such as EGFR-PTK, PI3K, CKII, MAPK and insulin receptor (IR). Necrosis-avid contrast agent investigated for use in non-invasively targeting necrotic tissues, based on to be defined components in the phospholipid bilayer.