Supplier: TCI America

Necrostatin-1 ≥98.0% (by HPLC)

Supplier: Enzo Life Sciences

Inhibits necroptosis

Supplier: Thermo Scientific Chemicals

Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.

Supplier: Thermo Scientific Chemicals

Necrostatin-1, Inactive Control

Supplier: Ambeed

For Research Use Only

Supplier: Adipogen

Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Cardioprotective and neuroprotective.