You searched for: Verapamil hydrochloride

Supplier: Thermo Scientific Chemicals

Verapamil hydrochloride 99+%

Supplier: TCI America

CAS Number: 152-11-4 MDL Number: MFCD00055208 Molecular Formula: C27H38N2O4 Molecular Weight: 491.07 Purity/Analysis Method: 98.0% (HPLC,T) Form: Crystal Color: White Melting point (°C): 145

Supplier: MP Biomedicals

(±)-Verapamil Hydrochloride is a α1-antagonist and calcium channel modulator.

Supplier: Enzo Life Sciences

Blocks slow voltage-sensitive L-type Ca2+ channels. Adrenergic antagonist. Inhibits platelet-activating factor and PMA-stimulated prostaglandin production in Kupffer cells. Induces apoptosis. In vitro resistance modifier in drug resistant human tumor cell lines.

Supplier: MilliporeSigma

A derivative of papaverine that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells

Supplier: Thermo Scientific Chemicals

A calcium channel blocker with a chemopreventive character

Supplier: Ambeed

Verapamil hydrochloride 99%

Supplier: Adipogen

Verapamil hydrochloride is an alpha-adrenergic receptor (alpha-AR) antagonist and calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein). Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models. Verapamil helps treat diabetes by limiting TXNIP expression.

Supplier: Adipogen

alpha1-Adrenergic receptor (alpha-AR) antagonist. Prototypical calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Vasodilator known to reduce the renal clearance of digoxin and used to control hypertension, angina, cardiac arrhythmia and vascular headaches. Apoptosis inducer in primary and metastatic colon adenocarcinoma human cell lines in vitro. Inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein) which are often over-expressed in certain tumor cell lines. Substrate of CYP3A4 and CYP2C6. Used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Anti-diabetic in animal models by limiting TXNIP expression.