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Specifications
- Antibody Type:Primary
- Antigen Symbol:Bim/BOD
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Form:Liquid
- Storage Buffer:PBS containing 0.02% sodium azide.
- Storage Temperature:+4°C
- Shipping Temperature:Blue Ice Not Frozen
- Immunogen:Synthetic peptide corresponding to the sequence near the middle of human Bim/BOD.
- Purification:purified by peptide affinity chromatography
- Cat. No.:10049-812
- Supplier no.:ADI-AAP-330-E
Specifications
About this item
Bim/BOD is a group of three splice variants, BimEL, BimL, and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bim is a critical regulator of lymphocyte homeostasis, acts as a barrier against autoimmune disease and is necessary for the apoptotic response to certain stress signals. All isoforms of Bim contain the C-terminal Bcl-2 homology domain known as BH3. Certain apoptotic stimuli release Bim from the complex which allows it to translocate to the mitochondria and bind to Bcl-2 or its homologues, thereby promoting apoptosis.
Type: Primary
Antigen: Bim/BOD
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat