You searched for: Proteins and Peptides

Supplier: VWR International

Resistin, also known as FIZZ3, is a peptide hormone belonging to a class of cysteine-rich secreted proteins termed the resistin-like molecules (RELM) family. Mouse resistin, produced by adipocytes, is involved in insulin resistance and modulates glucose homeostasis and adipogenesis.

Supplier: VWR International

Resistin is a peptide hormone belonging to a class of cysteine-rich secreted proteins, termed the resistin-like molecules (RELM) family. Resistin is produced by macrophages and functions during insulin sensitivity and inflammatory processes.

Supplier: VWR International

Neutrophil activating peptide 2 (NAP-2), also known as CXCL7, is a member of the CXC family of chemokines. NAP-2 is a carboxyl-terminal fragment produced by proteolytic cleavage of the platelet basic protein (PBP). NAP-2 is released from platelets and binds to the receptors CXCR1 and CXCR2 to chemoattract and activate neutrophils during inflammatory events. 

Supplier: VWR International

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

Supplier: MilliporeSigma

G-Protein βγ Binding Peptide

Supplier: VWR International

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

Supplier: VWR International

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

Supplier: VWR International

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

Supplier: Rockland Immunochemical

F-Box Protein Fbp5A Control Peptide

Supplier: MilliporeSigma

G-Protein βγ Binding Peptide, mSIRK

Supplier: VWR International

Monocyte chemotactic protein 3 (MCP-3), also called CCL7, is produced by macrophages and tumor cell lines. MCP-3 signals through the G protein-coupled receptors CCR1, CCR2, and CCR3. MCP-3 chemoattracts monocytes and regulates macrophage function during inflammation and metastasis.

Supplier: VWR International

Interleukin 7 (IL-7) is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes.

Supplier: VWR International

Ciliary neurotrophic factor (CNTF) is a neurotrophic factor that promotes the survival of neuronal cell populations, neurite outgrowth, and neurotransmitter synthesis. CNTF also plays an important protective role during nervous system injury.

Supplier: VWR International

Interferon gamma (IFN-γ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-γ is produced by T cells and natural killer cells following antigen-specific activation.

Supplier: VWR International

Cytokines for polarizing human T cells into Th17 cells. T helper 17 cells (Th17) are a distinct type of T cell subset that are thought to be important in immunity against microbes at the epitilial and mucosal interfaces of the body.

Supplier: VWR International

Cytokines for polarizing mouse T cells into Th17 cells. T helper 17 cells (Th17) are a distinct type of T cell subset that are thought to be important in immunity against microbes at the epitilial and mucosal interfaces of the body.

Supplier: VWR International

Growth regulated protein alpha (GRO-α), also known as CXCL1, is a chemokine that has mitogenic properties and is a neutrophil chemoattractant. GRO-α is secreted by macrophages, epithelial cells, neutrophils, and melanomas. GRO-α signals through the CXCR2 chemokine receptor and is important during spinal cord formation, inflammation, angiogenesis, tumorigenesis, and wound healing.

Supplier: VWR International

Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the tumor necrosis factor (TNF) family of proteins. RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. T cell expression of RANK Ligand promotes dendritic cell maturation.

Supplier: VWR International

Exodus-2, also known as CCL21 and 6Ckine, is a chemokine that is strongly produced in the human lymph nodes and spleen.  Exodus-2 signals through the chemokine receptor CCR7 to regulate thymocyte and activated T cell migration. Exodus-2 also mediates the homing of lymphocytes to the lymphatic system.

Supplier: VWR International

Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

Supplier: VWR International

Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta (TGF-β) family and is made by the placenta and cardiovascular tissues. GDF-15 regulates inflammatory and apoptotic pathways during cellular stress and injury.

Supplier: VWR International

Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways.

Supplier: VWR International

Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

Supplier: VWR International

Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.

Supplier: VWR International

Epithelial-derived neutrophil-activating peptide 78 (ENA 78), also known as CXCL5, is a chemokine that recruits neutrophils, promotes angiogenesis, and stimulates connective tissue remodelling. ENA 78 production is stimulated by interleukin 1 (IL-1) or tumor necrosis factor alpha (TNFα), and signals through the chemokine receptor CXCR2. ENA 78, 5-78aa is one of three naturally occurring ENA 78 variants in which the N-terminus has been truncated.

Supplier: VWR International

Fibroblast growth factor 6 (FGF-6) is a heparin-binding growth factor that is expressed in epithelial and mesenchymal lineages. FGF-6 binds and signals through the FGF receptors FGFR1, FGFR2, and FGFR4. FGF-6 functions as a mitogen for vascular endothelial cells and fibroblasts. FGF-6 is also an important factor driving muscle differentiation and regeneration.

Supplier: VWR International

Nerve growth factor beta (β-NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. β-NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. β-NGF is also involved in the growth, differentiation, and survival of B lymphocytes. Human, mouse, and rat β-NGF proteins are cross-reactive. 

Supplier: VWR International

Fractalkine, also known as CX3CL1, is a cytokine protein containing a CX3C chemokine motif atop a mucin stalk. Fractalkine is produced by non-hemopoietic cells, including neurons and astrocytes. Soluble fractalkine functions as a chemoattractant for T cells and monocytes. Cell-membrane-bound fractalkine, which is induced on activated endothelial cells, promotes leukocyte adhesion. The transmembrane chemokine receptor CX3CR1 mediates the adhesive and chemoattractant functions of fractalkine.

Supplier: VWR International

Interleukin 33 (IL-33) is a member of the IL-1 cytokine family and is constitutively expressed in smooth muscle and airway epithelial cells.  IL-33 signals through the interleukin 1 receptor-like 1 (IL-1R1) and interleukin-1 receptor accessory protein (IL1RAP) receptors to ativate NF-κB and MAPK signaling pathways.  IL-33 functions to induce type 2 cytokine production in polarized Type 2 helper T (Th2) cells.  

Supplier: VWR International

Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.