Order Entry
United Kingdom
ContactUsLinkComponent
42864 results for "ProSci Inc."

42864 Results for: "ProSci Inc."

Sort By
Anti-ASGR1 Rabbit Polyclonal Antibody

Anti-ASGR1 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

ASGR1 is a cell surface receptor binds to galactose-terminated glycoproteins. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface.

Expand 1 Items
Loading...
Anti-ATP7A Rabbit Polyclonal Antibody

Anti-ATP7A Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

The ATP7A gene encodes the Menkes copper-translocating P-type ATPase, a ubiquitous protein that regulates the absorption of copper in the gastrointestinal tract. Inside cells, this protein has a dual function: it delivers copper to cuproenzymes in the Golgi compartment and effluxes excess copper. The trafficking mechanism and catalytic activity combine to facilitate absorption and intercellular transport of copper. Menkes disease, a systemic copper deficiency disorder, is caused by mutations in the ATP7A gene.

Expand 1 Items
Loading...
Anti-ALB Chicken Polyclonal Antibody

Anti-ALB Chicken Polyclonal Antibody

Supplier: ProSci Inc.

Albumin Antibody: Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. It functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The resulting product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. At least two isoforms of Albumin are known to exist.

Expand 1 Items
Loading...
Anti-TTR Chicken Polyclonal Antibody

Anti-TTR Chicken Polyclonal Antibody

Supplier: ProSci Inc.

Transthyretin Antibody: Transthyretin is a tetrameric carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include familial amyloidotic polyneuropathy, euthyroid hyperthyroxinemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. It has also been suggested that Transthyretin plays an important role in the maintenance of normal cognitive processes during aging, neuropeptide processing and nerve regeneration. It has also been linked to several pathological conditions including Parkinson's disease, schizophrenia, and depression.

Expand 1 Items
Loading...
Anti-PTER Rabbit Polyclonal Antibody

Anti-PTER Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

PTER Antibody: PTER is a mammalian homolog to bacterial phosphotriesterases, enzymes that hydrolyze phosphotriester-containing organophosphate pesticides. It is expressed primarily in the proximal renal tubules and the gene has been localized in humans to chromosomal band 10p12 by in situ hybridization. PTER, in addition to FTO, MC4R, and NPC1 has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. At least two isoforms of PTER are known to exist.

Expand 1 Items
Loading...
Human REEP4 peptide (17 aa in the center)

Human REEP4 peptide (17 aa in the center)

Supplier: ProSci Inc.

REEP4 peptide is used for blocking the activity of REEP4 antibody.

Expand 1 Items
Loading...
Anti-APRIL Rabbit Polyclonal Antibody

Anti-APRIL Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

APRIL Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1 alpha (for TNF related death ligand 1 alpha ) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kappa B, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

Expand 1 Items
Loading...
Anti-DFF40 Rabbit Polyclonal Antibody

Anti-DFF40 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

DFF40 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD for caspase activated deoxyribonuclease. The human homologue of mouse CAD was more recently identified by three groups independently and termed CPAN, DFF40, and human CAD, respectively. DFF45/ICAD is the inhibitory protein of DFF40/CAD and forms complex with DFF40/CAD. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death.

Expand 1 Items
Loading...
Anti-PECAM1 Mouse Monoclonal Antibody

Anti-PECAM1 Mouse Monoclonal Antibody

Supplier: ProSci Inc.

CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors.It is constitutively expressed on the surface of endothelial cells, and concentrated at the junction between them. The antibody reacts with the murine form of the Platelet-Endothelial Cell Adhesion Molecule. The reactivity of the antibody is restricted to the isoform of the molecule that is selectively expressed by endothelial cells.The antigen is predominantly present at the lateral borders of endothelial cells as described for human PECAM-1.It is also weakly expressed on many peripheral lymphoid cells and platelets.CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas).

Expand 1 Items
Loading...
Human DC-SIGN peptide (17 aa near the extracellular domain)

Human DC-SIGN peptide (17 aa near the extracellular domain)

Supplier: ProSci Inc.

DC-SIGN peptide is used for blocking the activity of DC-SIGN antibody.

Expand 1 Items
Loading...
Anti-BLK Mouse Monoclonal Antibody

Anti-BLK Mouse Monoclonal Antibody

Supplier: ProSci Inc.

BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.

Expand 1 Items
Loading...
Anti-BAAT Rabbit Polyclonal Antibody

Anti-BAAT Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

BAAT is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene.

Expand 1 Items
Loading...

Human DAP kinase 2 peptide (15 aa near C-terminus)

Supplier: ProSci Inc.

DAP kinase 2 peptide is used for blocking the activity of DAP kinase 2 antibody.

Expand 1 Items
Loading...
Anti-CALR Rabbit Polyclonal Antibody

Anti-CALR Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

Expand 1 Items
Loading...

Mouse Caspase 12 peptide (16 aa near N-terminus)

Supplier: ProSci Inc.

Caspase-12 peptide is used for blocking the activity of caspase-12 antibody.

Expand 1 Items
Loading...
Anti-ZNF510 Rabbit Polyclonal Antibody

Anti-ZNF510 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

ZNF510 may be involved in transcriptional regulation.

Expand 1 Items
Loading...
Anti-ZNF777 Rabbit Polyclonal Antibody

Anti-ZNF777 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

The function remains unknown.

Expand 1 Items
Loading...

Human ECRG4 peptide (20 aa near C-terminus)

Supplier: ProSci Inc.

ECRG4 peptide is used for blocking the activity of ECRG4 antibody.

Expand 1 Items
Loading...
Anti-ZNF500 Rabbit Polyclonal Antibody

Anti-ZNF500 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

ZNF500 is a new candidate transcription factor.

Expand 1 Items
Loading...
Anti-NPNT Rabbit Polyclonal Antibody

Anti-NPNT Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

NPNT is a functional ligand of integrin alpha-8/beta-1 in kidney development. It regulates with integrin alpha-8/beta-1 the expression of GDNF which is essential for kidney development. It may also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.

Expand 1 Items
Loading...
Anti-TBX15 Rabbit Polyclonal Antibody

Anti-TBX15 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

TBX15 is a probable transcriptional regulator involved in developmental processes.

Expand 1 Items
Loading...

Mouse recombinant TIMP1

Supplier: ProSci Inc.

Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16. TIMP-1 does not act on MMP-14.

Expand 1 Items
Loading...

Mouse recombinant CD275 (from CHO cells)

Supplier: ProSci Inc.

Mouse B7-H2, also called CD275, B7RP-1, B7h, LICOS and GL50, is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.

Expand 1 Items
Loading...
Anti-Dchs1 Goat Polyclonal Antibody

Anti-Dchs1 Goat Polyclonal Antibody

Supplier: ProSci Inc.

Anti-Dchs1 Goat Polyclonal Antibody

Expand 1 Items
Loading...

Human recombinant CD275 (from CHO cells)

Supplier: ProSci Inc.

Human B7-H2 is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1), PD-L2 and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. B7-H2 has been identified as the ligand for ICOS, a member of the CD28 family of costimulatory receptors. Human B7-H2 is expressed constitutively on resting B cells, dendritic cells and at low levels on monocytes. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.

Expand 1 Items
Loading...

Mouse recombinant CD74

Supplier: ProSci Inc.

Mouse HLA class II histocompatibility antigen gamma chain (CD74), is a single-pass type II membrane protein that in humans is encoded by the CD74 gene. It contains 1 thyroglobulin type-1 domain. CD74 Plays a critical role in MHC class II antigen processing by stabilising peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

Expand 1 Items
Loading...
Human SHANK3 peptide

Human SHANK3 peptide

Supplier: ProSci Inc.

SHANK3 peptide is used for blocking the activity of SHANK3 antibody.

Expand 1 Items
Loading...
Anti-NDE1 Rabbit Polyclonal Antibody

Anti-NDE1 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

NDE1 is required for centrosome duplication and formation and function of the mitotic spindle. It is essential for the development of the cerebral cortex. NDE1 may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex

Expand 1 Items
Loading...
Anti-HDGFRP2 Rabbit Polyclonal Antibody

Anti-HDGFRP2 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

HDGFRP2 Antibody: Hepatoma-derived growth factor-related protein 2 (HDGFRP2) is a widely expressed member of protein family that contains the HDGF related proteins 1-4 and lens epithelial derived growth factor (LEDGF). These family members show extensive homology at the amino terminus (termed the hath region). Little is known of the role of HDGFRP2, but like the related LEDGF, HDGFRP2 can bind HIV-1 integrase and stimulate HIV-1 integrase activity in vitro.

Expand 1 Items
Loading...
Anti-SPRYD5 Rabbit Polyclonal Antibody

Anti-SPRYD5 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

SPRYD5 Antibody: The SPRY domain-containing protein 5 (SPRYD5) is a member of a family of proteins whose sole common characteristic is the presence of a SPRY domain. SPRY domains are structural domains that were first described in the fungal Dictyostelium discoideum tyrosine kinase spore lysis A. In most systems SPRY domains provide binding sites for regulatory proteins or intramolecular binding sites that maintain the structural integrity of a protein. SPRYD5 belongs to the TRIM/RBCC family and contains one B box-type zinc finger, one B30.2/SPRY domain and one RING-type zinc finger. Little is known of the function of the SPRYD5 protein.

Expand 1 Items
Loading...
Sort By
Recommended for You