1282 Results for: "MEDCHEMEXPRESS"

Supplier: MEDCHEMEXPRESS

Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of H ER2-targeting ADC (DS-8201a). 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M- CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold 1 * 10 g

Supplier: MEDCHEMEXPRESS

Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule ass embly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, 1 * 50 mg

Supplier: MEDCHEMEXPRESS

BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phos phorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specif 1 * 100 mg

Supplier: MEDCHEMEXPRESS

VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monometh yl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). 1 * 500 mg

Supplier: MEDCHEMEXPRESS

Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 1 1 * 200 mg

Supplier: MEDCHEMEXPRESS

4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen (( Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation[1][2][3][4]. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin induces HIF1 expression a 1 * 5 mg

Supplier: MEDCHEMEXPRESS

UK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 (PF-1005023) inhibits pyruvate-depen dent O2 consumption with an IC50 of 50 nM. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Silmitasertib (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Saruparib (AZD5305) is a potent, orally active and selective PARP inhibitor and trapper with IC50 values of 3 nM and 1400 nM for PAR P1 and PARP2, respectively. Saruparib has anti-proliferative activity and inhibits growth in cells with deficiencies 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in nor 1 * 1 Each

Supplier: MEDCHEMEXPRESS

Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM. Temsirolimus activates autophagy and prevents deterioration of cardiac function in animal model[8]. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus. 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high a ffinity to cereblon, resulting in potent antimyeloma activity[1]. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydr oxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable sa 1 * 100 mg

Supplier: MEDCHEMEXPRESS

NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Troglitazone is an orally active PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively. T roglitazone has anticancer activity, prevents and inhibits the development of type 2 diabetes. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model[1]. EED226 is a potent, selective, and orally bioavailab 1 * 25 mg

Supplier: MEDCHEMEXPRESS

Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs, inhibiting CDK1, CDK2, CDK4 with IC50s of 30, 170, 1 00 nM, respectively. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. 1 * 500 mg

Supplier: MEDCHEMEXPRESS

IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectivel y. 1 * 200 mg

Supplier: MEDCHEMEXPRESS

Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150 nM for cereblon -binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities 1 * 50 mg

Supplier: MEDCHEMEXPRESS

HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 26 1 * 25 mg

Supplier: MEDCHEMEXPRESS

Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL 1) activity even at concentrations as high as 440 μM[1]. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[1]. 1 * 200 mg

Supplier: MEDCHEMEXPRESS

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proaut ophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of 1 * 100 mg