1277 Results for: "MEDCHEMEXPRESS"
IACS-010759 is an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 inhibit s proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. I 1 * 25 mg
Supplier: MEDCHEMEXPRESS
IACS-010759 is an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 inhibit s proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. I 1 * 25 mg
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GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1. 3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMG 1 * 1 mg
Supplier: MEDCHEMEXPRESS
GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1. 3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMG 1 * 1 mg
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A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8?nM and 2.6?nM for p300 and CBP histone acetyltrans ferase (HAT), respectively[1]. 1 * 100 mg
Supplier: MEDCHEMEXPRESS
A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8?nM and 2.6?nM for p300 and CBP histone acetyltrans ferase (HAT), respectively[1]. 1 * 100 mg
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Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM[2]. 1 * 5 mg
Supplier: MEDCHEMEXPRESS
Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM[2]. 1 * 5 mg
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T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibit s the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-in 1 * 50 mg
Supplier: MEDCHEMEXPRESS
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibit s the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-in 1 * 50 mg
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Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunos uppressant. 1 * 200 mg
Supplier: MEDCHEMEXPRESS
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunos uppressant. 1 * 200 mg
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Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK 2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK 1 * 5 mg
Supplier: MEDCHEMEXPRESS
Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK 2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK 1 * 5 mg
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Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC 50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling mole 1 * 5 mg
Supplier: MEDCHEMEXPRESS
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC 50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling mole 1 * 5 mg
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Buparlisib (BKM120 NVP-BKM120) is a pan-class I PI3K inhibitor, with IC50s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p 110γ, respectively. 1 * 5 mg
Supplier: MEDCHEMEXPRESS
Buparlisib (BKM120 NVP-BKM120) is a pan-class I PI3K inhibitor, with IC50s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p 110γ, respectively. 1 * 5 mg
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(R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132[1]. 1 * 100 mg
Supplier: MEDCHEMEXPRESS
(R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132[1]. 1 * 100 mg
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Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activ ity. Lorlatinib has Kis of L1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation wit 1 * 10 mg
Supplier: MEDCHEMEXPRESS
Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activ ity. Lorlatinib has Kis of L1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation wit 1 * 10 mg
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Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport i nto cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. 1 * 25 mg
Supplier: MEDCHEMEXPRESS
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport i nto cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. 1 * 25 mg
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Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1]. 1 * 5 mg
Supplier: MEDCHEMEXPRESS
Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1]. 1 * 5 mg
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IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformati onal change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduce 1 * 50 mg
Supplier: MEDCHEMEXPRESS
IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformati onal change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduce 1 * 50 mg
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Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron acc umulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxam 1 * 5 mg
Supplier: MEDCHEMEXPRESS
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron acc umulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxam 1 * 5 mg
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ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylatio n (IC50=5 nM). 1 * 10 mg
Supplier: MEDCHEMEXPRESS
ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylatio n (IC50=5 nM). 1 * 10 mg
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Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer[1][2]. 1 * 500 mg
Supplier: MEDCHEMEXPRESS
Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer[1][2]. 1 * 500 mg
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CGP37157 is a potent, selective inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitoc hondria, with an IC50 of 0.8 μM. 1 * 5 mg
Supplier: MEDCHEMEXPRESS
CGP37157 is a potent, selective inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitoc hondria, with an IC50 of 0.8 μM. 1 * 5 mg
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EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H +-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and ca 1 * 100 mg
Supplier: MEDCHEMEXPRESS
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H +-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and ca 1 * 100 mg
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INHIBITOR MLN-4760 HUMAN ACE2 1 * 10 mg
Supplier: MEDCHEMEXPRESS
INHIBITOR MLN-4760 HUMAN ACE2 1 * 10 mg
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UNC10217938A/ 3-DEAZAPTERIDINE ANALOG WITH STRONG OLIGONUCLEOTIDE ENHANCING EFFECTS. 1 * 10 mg
Supplier: MEDCHEMEXPRESS
UNC10217938A/ 3-DEAZAPTERIDINE ANALOG WITH STRONG OLIGONUCLEOTIDE ENHANCING EFFECTS. 1 * 10 mg
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YAP/TAZ INHIBITOR-1 1 * 100 mg
Supplier: MEDCHEMEXPRESS
YAP/TAZ INHIBITOR-1 1 * 100 mg
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Sepantronium bromide (YM-155) is a survivin inhibitor with an IC50 of 0.54 nM[1]. 1 * 5 mg
Supplier: MEDCHEMEXPRESS
Sepantronium bromide (YM-155) is a survivin inhibitor with an IC50 of 0.54 nM[1]. 1 * 5 mg
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Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the G ABA degradating enzyme GABA-T. 1 * 1 g
Supplier: MEDCHEMEXPRESS
Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the G ABA degradating enzyme GABA-T. 1 * 1 g
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Rosnilimab is a humanized IgG1-κ antibody targeting to PD-1[1][2]. 1 * 10 mg
Supplier: MEDCHEMEXPRESS
Rosnilimab is a humanized IgG1-κ antibody targeting to PD-1[1][2]. 1 * 10 mg
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Darolutamide (ODM-201 BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in in vitro assay. 1 * 5 mg
Supplier: MEDCHEMEXPRESS
Darolutamide (ODM-201 BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in in vitro assay. 1 * 5 mg
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