1277 Results for: "MEDCHEMEXPRESS"

Supplier: MEDCHEMEXPRESS

Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survi val of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons[1]. GDNF Protein, 1 * 2 µG

Supplier: MEDCHEMEXPRESS

RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin (HY-10219) with MLN0128 (HY-13328, a second-generation mTOR kinase inhibitor) by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inh 1 * 10 mg

Supplier: MEDCHEMEXPRESS

BAI1 is a selective and allosteric inhibitor of BAX, an apoptosis regulator. BAI1 directly binds to BAX and allosterically inhibits BAX activation. BAI1 has the potential for the research of diseases mediated by BAX-dependent cell death[1]. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Foretinib is a multi-target tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

C646 is a selective and competitive histone acetyltransferase p300 inhibitor with Ki of 400 nM, and is less potent for other acetylt ransferases[1]. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor (IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I is also a GSK-3 inhibitor[1][2][3]. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cystei ne residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity[1][ 1 * 10 mg

Supplier: MEDCHEMEXPRESS

TAK-243 1 * 1 mL

Supplier: MEDCHEMEXPRESS

STING agonist-4 ,98% 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Fmoc-3VVD-OH(Purity 98%) 1 * 1 g

Supplier: MEDCHEMEXPRESS

Skp2 inhibitor 1 (1 mg) 1 * 1 mg

Supplier: MEDCHEMEXPRESS

ONO-7475 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Azelaprag 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide has the potential for type 2 diabetes treatment. 1 * 1 mg

Supplier: MEDCHEMEXPRESS

AZD3965 is a selective MCT1 inhibitor with a Ki of 1.6 nM, showing 6-fold selectivity over MCT2. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells 1 * 200 mg

Supplier: MEDCHEMEXPRESS

PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 μM Ki=5.9 nM). PLX5622 allows for exten ded and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desir 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM)[1]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Wortmannin (SL-2052 KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks a utophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectivel 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IF N-α. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, resp ectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Ulixertinib (BVD-523 VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of [1][2]. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Rucaparib (AG014699) is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP 1. Rucaparib is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib has the potential for castratio 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan s hows anticancer activity[1]. 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activa ting and antineoplastic activities[1][2]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor[1][ 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Brigatinib (AP-26113) is a highly potent, selective and orally active ALK inhibitor, with an IC50 of 0.6 nM. Brigatinib can be used for research of NSCLC[1]. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 is also a known degrader of GSPT1, inhibiting protein translation. 1 * 10 mg