1278 Results for: "MEDCHEMEXPRESS"

Supplier: MEDCHEMEXPRESS

Icosabutate, an orally active ω-3 polyunsaturated fatty acid, is an aeicosapentaenoic acid (EPA) derivative. Icosabutate overcomes t he drawbacks of unmodified EPA for liver targeting and improves insulin sensitivity, hepatic inflammation and fibrosi 1 * 5 mg

Supplier: MEDCHEMEXPRESS

AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitum or activity[1]. 1 * 250 mg

Supplier: MEDCHEMEXPRESS

STM2457 is a first-in-class, highly potent, selective and orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be use d for the research of acute myeloid leukaemia (AML)[1][2]. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 prote in, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and ina 1 * 2 mg

Supplier: MEDCHEMEXPRESS

Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, re spectively. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis[1]. 1 * 1 mg

Supplier: MEDCHEMEXPRESS

GSK126 (GSK2816126A) is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC50 of 9.9 nM[1]. 1 * 200 mg

Supplier: MEDCHEMEXPRESS

Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conform 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Entinostat is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, re spectively. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

RMC-9805 (KRAS G12D inhibitor 18) is a KRAS G12D inhibitor. RMC-9805 is orally active. RMC-9805 inhibits RAS signaling to induce apo ptosis in KRAS G12D mutant cancer cells[1][2]. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

740 Y-P (740YPDGFR PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containin g both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone[1]. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibit or. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina 1 * 50 mg

Supplier: MEDCHEMEXPRESS

MK8722 is a potent and systemic pan-AMPK activator. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity. 1 * 500 mg

Supplier: MEDCHEMEXPRESS

BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 μM. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits prolifera 1 * 25 g

Supplier: MEDCHEMEXPRESS

Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 3.3 μM, 4.7 μM, 32 μM, 3.7 μM and 9.2 μM for SARS-CoV-2 and its variants alpha, beta, gamma and delta, respectively. Remdesivir is highly effective in the co 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM a nd an IC50 of 50=8 nM) and RSK1 (IC50=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastro 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor[1]. Z-VAD(OMe)-FMK is an ubiquiti n carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active 1 * 50 mg

Supplier: MEDCHEMEXPRESS

RRibociclib (LEE011) is an ATP-competitive and orally active CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1][1]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275 ) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and a 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Midostaurin (PKC412 CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β /γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1][2]. Mido 1 * 100 mg

Supplier: MEDCHEMEXPRESS

FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1]. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectiv ely inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 value s of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumo 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Palbociclib (PD 0332991) monohydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, r espectively. Palbociclib monohydrochloride has potent anti-proliferative activity and induces cell cycle arrest in ca 1 * 200 mg

Supplier: MEDCHEMEXPRESS

U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 µM for PLC. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5 ) site of the 20S proteasome with an IC50 of 3.4 nM (Ki of 0.93 nM). 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosi s induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activat 1 * 5 mg

Supplier: MEDCHEMEXPRESS

STC-15 is an orally active RNA methyltransferase METTL3 inhibitor with the activity of activating anti-tumor immunity and reshaping the tumor microenvironment. STC-15 inhibits tumor growth by activating anti-cancer immune responses associated with in 1 * 5 mg