1282 Results for: "MEDCHEMEXPRESS"

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TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1]. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1]. 1 * 25 mg

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MCC950 (CP-456773 CRID3) is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

MCC950 (CP-456773 CRID3) is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. 1 * 5 mg

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Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-in hibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory 1 * 5 g

Supplier: MEDCHEMEXPRESS

Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-in hibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory 1 * 5 g

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Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline shows antibacte rial activity and anti-cancer cell proliferation activity[1][2][3][4][5]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline shows antibacte rial activity and anti-cancer cell proliferation activity[1][2][3][4][5]. 1 * 100 mg

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BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 1 92, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment[1]. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 1 92, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment[1]. 1 * 10 mg

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Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtema dlin binds to MDM2 with a Kd of 0.045 nM[1][2]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtema dlin binds to MDM2 with a Kd of 0.045 nM[1][2]. 1 * 100 mg

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Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhi 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhi 1 * 10 mg

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Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall c omponent β-(l,3)-D-glucan[1][2]. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall c omponent β-(l,3)-D-glucan[1][2]. 1 * 25 mg

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2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct preven ts neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervou 1 * 10 mg

Supplier: MEDCHEMEXPRESS

2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct preven ts neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervou 1 * 10 mg

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Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4]. 1 * 1 g

Supplier: MEDCHEMEXPRESS

Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4]. 1 * 1 g

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Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage[1][2]. 1 * 5 g

Supplier: MEDCHEMEXPRESS

Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage[1][2]. 1 * 5 g

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Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous recept or for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous recept or for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). 1 * 1 mg

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Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017) , a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining w 1 * 200 mg

Supplier: MEDCHEMEXPRESS

Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017) , a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining w 1 * 200 mg

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Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. 1 * 100 mg

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Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patr 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patr 1 * 5 mg

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DS21150768 is a potent, orally active HPK1 inhibitor. DS21150768 shows potent activity to enhance T-cell function. DS21150768 has an ticancer effects[1]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

DS21150768 is a potent, orally active HPK1 inhibitor. DS21150768 shows potent activity to enhance T-cell function. DS21150768 has an ticancer effects[1]. 1 * 100 mg

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Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent en donuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RN 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent en donuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RN 1 * 50 mg

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Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor. 1 * 100 mg

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Infigratinib (BGJ-398 NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Infigratinib (BGJ-398 NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. 1 * 100 mg

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Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor. 1 * 5 mg

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Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrat e has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC va 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrat e has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC va 1 * 50 mg

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Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors b inding studies are generally used for the latter receptor. 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors b inding studies are generally used for the latter receptor. 1 * 1 mg

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PKR-IN-C16 (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. PKR-IN-C16 shows promising neu roprotective properties and can rescue acute brain lesions[1]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

PKR-IN-C16 (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. PKR-IN-C16 shows promising neu roprotective properties and can rescue acute brain lesions[1]. 1 * 100 mg

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SB-590885 is a potent?B-Raf?inhibitor with?Ki?of 0.16 nM, and has 11-fold greater selectivity for B-Raf over c-Raf, without inhibiti on to other human kinases. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

SB-590885 is a potent?B-Raf?inhibitor with?Ki?of 0.16 nM, and has 11-fold greater selectivity for B-Raf over c-Raf, without inhibiti on to other human kinases. 1 * 100 mg

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Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculiz umab inhibits the cleavage of C5 into C5a and C5b and hence inhibits deployment of the terminal complement system inc 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculiz umab inhibits the cleavage of C5 into C5a and C5b and hence inhibits deployment of the terminal complement system inc 1 * 10 mg

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Vadimezan (DMXAA ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon gen es (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan has anti-influenza virus H1N1-PR8 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Vadimezan (DMXAA ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon gen es (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan has anti-influenza virus H1N1-PR8 1 * 5 mg