1282 Results for: "MEDCHEMEXPRESS"

Supplier: MEDCHEMEXPRESS

Linsitinib (OSI-906) is a potent, selective and orally bioavailable dual inhibitor of the IGF-1 receptor and insulin receptor (IR) w ith IC50s of 35 and 75 nM, respectively[1]. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

KVS0001 is a potent inhibitor of SMG1 and nonsense mediated decay (NMD) that has anti-tumor activity[1]. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM[1]. 1 * 2 mg

Supplier: MEDCHEMEXPRESS

8-Bromo-cAMP sodium (8-Br-Camp) sodium salt, a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Br omo-cAMP sodium salt has anti-proliferative and apoptotic effects against cancer cells[1][2]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki va lues of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of mu 1 * 5 mg

Supplier: MEDCHEMEXPRESS

TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing huma n immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC50 val 1 * 10 mg

Supplier: MEDCHEMEXPRESS

E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Tucidinostat (Chidamide) is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no / 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0 .24, 0.37, 0.32 nM, respectively. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantro lene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca2+ from RyR1 and RyR3, which c 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. 1 * 1 g

Supplier: MEDCHEMEXPRESS

STX-478 (compound 80) is an oral CNS-penetrant allosteric mutant-selective PI3Kα inhibitor. STX-478 shows robust and durable tumor r egression and can be used in cancer research[1]. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more poten tly. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate) JTP-74057 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis[1][2]. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Oritavancin diphosphate (LY333328 diphosphate), a semisynthetic derivative of Vancomycin (HY-B0671), is an orally active glycopeptid e antibiotic with bactericidal activity against gram-positive organisms. Oritavancin diphosphate shows antibacterial 1 * 2 mg

Supplier: MEDCHEMEXPRESS

XMU-MP-1 is a reversible and selective MST1/2 inhibitor with IC50s of 71.1 and 38.1 nM, respectively[1]. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells[1][2]. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti -orthopoxvirus and anti-variola activities. 1 * 500 mg

Supplier: MEDCHEMEXPRESS

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in res 1 * 5 mg

Supplier: MEDCHEMEXPRESS

CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects. 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a fa ster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively re 1 * 1 g

Supplier: MEDCHEMEXPRESS

C75 is a synthetic fatty-acid synthase (FASN) inhibitor inhibits prostate cancer cells PC3 with an IC50 of 35 μM[1][2][3]. C75 is a potent CPT1A activator[5]. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids[1]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Peanut Agglutinin (Rhodamine) 5mg 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both is oforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (I 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Atirmociclib (PF-07220060 example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/ Cyclin D3, respectively[1]. 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stag e in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria 1 * 500 mg

Supplier: MEDCHEMEXPRESS

ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic rele ase through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehic 1 * 500 mg