1243 Results for: "MEDCHEMEXPRESS"

Sort By

Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mit ochondrial targeted HSP90 inhibitor with anti-cancer activity. 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mit ochondrial targeted HSP90 inhibitor with anti-cancer activity. 1 * 1 mg

Expand 1 Items

Semaxinib (SU5416) is a potent and selective inhibitor of VEGFR (Flk-1/KDR) with an IC50 of 1.23 μM[1]. 1 * 500 mg

Supplier: MEDCHEMEXPRESS

Semaxinib (SU5416) is a potent and selective inhibitor of VEGFR (Flk-1/KDR) with an IC50 of 1.23 μM[1]. 1 * 500 mg

Expand 1 Items

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine DON) is a glutamine antagonist that irreversibly inhibits the catabolic effe ct of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and red 1 * 50 mg

Supplier: MEDCHEMEXPRESS

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine DON) is a glutamine antagonist that irreversibly inhibits the catabolic effe ct of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and red 1 * 50 mg

Expand 1 Items

Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respect ively. Palbociclib isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respect ively. Palbociclib isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, 1 * 100 mg

Expand 1 Items

U0126 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor[1][2][3][4]. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

U0126 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor[1][2][3][4]. 1 * 25 mg

Expand 1 Items

dTAGV-1 TFA is a potent and selective degrader of mutant FKBP12F36V fusion proteins. dTAGV-1 TFA can induce degradation of FKBP12F36 V-Nluc in vivo[1]. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

dTAGV-1 TFA is a potent and selective degrader of mutant FKBP12F36V fusion proteins. dTAGV-1 TFA can induce degradation of FKBP12F36 V-Nluc in vivo[1]. 1 * 25 mg

Expand 1 Items

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against 1 * 10 mg

Expand 1 Items

Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K 1 * 25 mg

Supplier: MEDCHEMEXPRESS

Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K 1 * 25 mg

Expand 1 Items

ARV-825 is a PROTAC connected by ligands for Cereblon and BRD4. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respe ctively. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

ARV-825 is a PROTAC connected by ligands for Cereblon and BRD4. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respe ctively. 1 * 50 mg

Expand 1 Items

Clavulanic acid is a naturally occurring powerful bacterial β-lactamases inhibitor for research of infections caused by bacteria, in cluding infections of the ears. Clavulanic acid is active against a wide spectrum of gram-positive and gram-negative 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Clavulanic acid is a naturally occurring powerful bacterial β-lactamases inhibitor for research of infections caused by bacteria, in cluding infections of the ears. Clavulanic acid is active against a wide spectrum of gram-positive and gram-negative 1 * 10 mg

Expand 1 Items

Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively. 1 * 10 mg

Expand 1 Items

Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor, with IC50 of 0.2 nM-3.5 nM[1]. Asunaprevir inhibits SARS-CoV-2 3CLpro activity[5]. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor, with IC50 of 0.2 nM-3.5 nM[1]. Asunaprevir inhibits SARS-CoV-2 3CLpro activity[5]. 1 * 5 mg

Expand 1 Items

4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross -links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial 1 * 10 mg

Supplier: MEDCHEMEXPRESS

4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross -links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial 1 * 10 mg

Expand 1 Items

Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5]. 1 * 100 mg

Expand 1 Items

TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in nor 1 * 1 Each

Supplier: MEDCHEMEXPRESS

TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in nor 1 * 1 Each

Expand 1 Items

IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. 1 * 25 mg

Expand 1 Items

Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM. 1 * 100 mg

Expand 1 Items

Nedisertib (M3814) is a potent, orally available and selective inhibitor of DNA-PK, with an IC50 of [1][2][3]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Nedisertib (M3814) is a potent, orally available and selective inhibitor of DNA-PK, with an IC50 of [1][2][3]. 1 * 100 mg

Expand 1 Items

Zampilimab (UCB-7858) is a monoclonal antibody against transglutaminase 2 (TG2). Zampilimab has potential application in renal trans plant[1][2]. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Zampilimab (UCB-7858) is a monoclonal antibody against transglutaminase 2 (TG2). Zampilimab has potential application in renal trans plant[1][2]. 1 * 5 mg

Expand 1 Items

MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader. MS934 also degrades CRAF. MS934 can be used for the research of va riety of human cancers, such as melanoma, nonsmall cell lung cancer (NSCLC), colorectal cancer, primary brain tumors, 1 * 1 mg

Supplier: MEDCHEMEXPRESS

MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader. MS934 also degrades CRAF. MS934 can be used for the research of va riety of human cancers, such as melanoma, nonsmall cell lung cancer (NSCLC), colorectal cancer, primary brain tumors, 1 * 1 mg

Expand 1 Items

MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respec tively. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respec tively. 1 * 50 mg

Expand 1 Items

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle. 1 * 10 mg

Expand 1 Items

SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, i ncreases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-produc 1 * 5 mg

Supplier: MEDCHEMEXPRESS

SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, i ncreases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-produc 1 * 5 mg

Expand 1 Items

IRF5-IN-1 (compound C5) is an IRF5 pathway-specific inhibitor. IRF5-IN-1 significantly reduces IRF5 nuclear translocation without af fecting the activation of NF-κB p65. IRF5-IN-1 acts through SLC15A4 to selectively inhibit TLR7/8-induced IRF5 respon 1 * 5 mg

Supplier: MEDCHEMEXPRESS

IRF5-IN-1 (compound C5) is an IRF5 pathway-specific inhibitor. IRF5-IN-1 significantly reduces IRF5 nuclear translocation without af fecting the activation of NF-κB p65. IRF5-IN-1 acts through SLC15A4 to selectively inhibit TLR7/8-induced IRF5 respon 1 * 5 mg

Expand 1 Items

Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of u 1 * 500 mg

Supplier: MEDCHEMEXPRESS

Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of u 1 * 500 mg

Expand 1 Items

Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PE G4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-Val-C 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PE G4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-Val-C 1 * 50 mg