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Xevinapant (AT-406) is a potent and orally bioavailable Smac mimetic and an antagonist of IAPs, and it binds to XIAP, cIAP1, and cIA P2 proteins with Ki of 66.4, 1.9, and 5.1 nM, respectively. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochlori 1 * 5 mg

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Volasertib (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and 1 * 5 mg

Supplier: MEDCHEMEXPRESS

Daporinad (FK866) is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase Nampt) with an IC50 of 0.09 nM. 1 * 50 mg

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Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multip le myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to prot 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Nutlin-3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0[1][2].. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM[1]. 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFR β, respectively. 1 * 50 mg

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Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chroni c alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in 1 * 5 g

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AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy[1]. AS1842856 reduces Foxo1 activity and, to a les ser extent, inhibits Foxo1 protein expression by simply binding to Foxo1[2]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1[1]. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM[1][2]. 1 * 10 mg

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Sotuletinib (BLZ945) is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing more than 1,0 00-fold selectivity against its closest receptor tyrosine kinase homologs[1]. 1 * 100 mg

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MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β m 1 * 5 mg

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LGK974 (WNT974) is an orally bioavailable and specific Porcupine (PORCN) inhibitor with an IC50 of 0.1 nM[1]. 1 * 100 mg

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PROTAC TYK2 degradation agent1 is a potent and subtype-selective TYK2 degrader. PROTAC TYK2 degradation agent1 has TYK2 degradation activity with DC50 value of 14 nM. PROTAC TYK2 degradation agent1 can be used for the research of autoimmune disease[1 1 * 50 mg

Supplier: MEDCHEMEXPRESS

TAMRA azide, 5-isomer is a click chemical containing azide groups that can be used as a linker for the orange dye TAMRA. The azide g roup of TAMRA Azide, 5-isomer enables copper-catalyzed click chemical reactions with alkynes, DBCO, and BCN[1][2]. It 1 * 10 mg

Supplier: MEDCHEMEXPRESS

BDP FL azide is a BDP dye connector containing an azide group capable of Click Chemistry. The green fluorophore is representative of the borodipyrromethane class of fluorescent dyes and has a high quantum yield in aqueous environments, high stabilit 1 * 5 mg

Supplier: MEDCHEMEXPRESS

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to E. coli LpxC with a Ki of 4.0 nM. CHIR-090 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition 1 * 5 mg

Supplier: MEDCHEMEXPRESS

ALC-0159, a polyethylene glycol (PEG) lipid conjugate, could be used as vaccine excipient. 1 * 5 mg

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Sofituzumab (MMUC 1206A) is a humanizedized anti-MUC16 recombinant V-kappa antibody[1]. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

2-Phenyl-2-(1-piperidinyl)propane is a selective and reversible human CYP2B6 inhibitor with an IC50 of 5.1 μM and a Ki of 5.6. 2-Phe nyl-2-(1-piperidinyl)propane inhibits CYP2D6 (IC50=74 μM), CYP3A (IC50=200 μM)[1]. 1 * 25 mg

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Divarasib (Synonyms: GDC-6036) 200mg 1 * 200 mg

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CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1] . 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX -M-15 with IC50s of 8 nM and 5 nM, respectively[1]. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. 1 * 500 mg

Supplier: MEDCHEMEXPRESS

Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727)[1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3[2]. Stattic ameliorates the renal dysfunction in Alport syndrome 1 * 25 mg

Supplier: MEDCHEMEXPRESS

5-Azacytidine (Azacitidine 5-AzaC Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5- Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic 1 * 200 mg

Supplier: MEDCHEMEXPRESS

Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbo ciclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the 1 * 50 mg