Supplier: MEDCHEMEXPRESS

Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor. Cirtuvivint can be used for solid tumors resear ch[1]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

BI-4916 is a proagent of BI-4924. BI-4924 is a NADH/NAD+-competitive PHGDH inhibitor[1]. 1 * 25 mg

Supplier: MEDCHEMEXPRESS

GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxalo acetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 plays an important role in energy metabolism and Reactive 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Danuglipron (PF-06882961) is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist. Danuglipron has the potential for t ype 2 diabetes research[1][2]. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promote s tumor cell apoptosis[1]. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblo n and induces degradation of essential Ikaros transcription factors. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Idelalisib (CAL-101 GS-1101) is a highly selective and orally bioavailable p110δ inhibitor with an IC50 of 2.5 nM, showing 40- to 3 00-fold selectivity for p110δ over other PI3K class I enzymes. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (m 1 * 100 mg

Supplier: MEDCHEMEXPRESS

Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3]. 1 * 500 mg

Supplier: MEDCHEMEXPRESS

Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity inhibits RMG1 and RMG2 cell growth w ith IC50 values of 1.25 and 1.16 nM, respectively. 1 * 5 mg

Supplier: MEDCHEMEXPRESS

AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon reson ance (SPR) assay[1]. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

ARV-825 is a PROTAC connected by ligands for Cereblon and BRD4. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respe ctively. 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Clavulanic acid is a naturally occurring powerful bacterial β-lactamases inhibitor for research of infections caused by bacteria, in cluding infections of the ears. Clavulanic acid is active against a wide spectrum of gram-positive and gram-negative 1 * 10 mg

Supplier: MEDCHEMEXPRESS

MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29?μM in human vitro. MKC8866 stron gly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52?μM and un 1 * 5 mg

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Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively. 1 * 10 mg

Supplier: MEDCHEMEXPRESS

Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydr oxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable sa 1 * 100 mg

Supplier: MEDCHEMEXPRESS

NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD. 1 * 100 mg

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Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs, inhibiting CDK1, CDK2, CDK4 with IC50s of 30, 170, 1 00 nM, respectively. 1 * 100 mg

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Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. 1 * 500 mg

Supplier: MEDCHEMEXPRESS

IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectivel y. 1 * 200 mg

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Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150 nM for cereblon -binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities 1 * 50 mg

Supplier: MEDCHEMEXPRESS

Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of H ER2-targeting ADC (DS-8201a). 1 * 1 mg

Supplier: MEDCHEMEXPRESS

Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M- CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold 1 * 10 g

Supplier: MEDCHEMEXPRESS

Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule ass embly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, 1 * 50 mg

Supplier: MEDCHEMEXPRESS

BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phos phorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specif 1 * 100 mg

Supplier: MEDCHEMEXPRESS

VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monometh yl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). 1 * 500 mg

Supplier: MEDCHEMEXPRESS

Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 1 1 * 200 mg

Supplier: MEDCHEMEXPRESS

Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5]. 1 * 100 mg

Supplier: MEDCHEMEXPRESS

TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in nor 1 * 1 Each