17481 Results for: "ENZO LIFE SCIENCES"

Olomoucine is a purine derivative which acts as a potent and selective inhibitor of CDK1 (p34cdc2)/cyclin B and related kinases. It acts by competing for the ATP binding domain of the kinase. Of 35 protein kinases tested, olomoucine inhibited p33CDK2/cyclin A, p33CDK2/cyclin E, p34cdc2/cyclin B, p33CDK5/p35 and erk1 with IC50 of 7, 7, 7, 3 and 25µM respectively. The related kinases p34CDK4/cyclin D and p40CDK6/cyclin D3 were not inhibited or were less sensitive to olomoucine, IC50 > 1000 and 250µM respectively. PKC, PKA, PKG, CaM kinase II, MLC kinase, CK2, EGFR tyrosine kinase, p56lck, p56lyn, p60c-src, v-abl and insulin receptor tyrosine kinase are not inhibited or are weakly inhibited at 1mM. It delays mouse oocyte maturation and inhibits the growth of a variety of human cell lines including Rhabdomyosarcoma cell line Rh1, Rh18, Rh28 and Rh30; MCF-7, KB-3-1 and their adriamycin-resistant counterparts (IC50=18-86µM). It inhibits DNA synthesis in interleukin-2-stimulated T lymphocytes and triggers a G1 arrest similar to interleukin-2 deprivation. Can be used to synchronize cells in G1. Triggers apoptosis in target tumor cells in vitro and in vivo and in maturing cerebellar granule neurons. N9-Isopropyl-olomoucine and the negative control Iso-olomoucine are also available.

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Pifithrin-mu ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

HSP70 inhibitor

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Z-DEVD-pNA

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Caspase substrate

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Oxamflatin ≥95% (by HPLC)

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HDAC inhibitor

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Geranylgeranylpyrophosphate triammonium salt 1mg/ml ≥98%

Supplier: ENZO LIFE SCIENCES

Geranylgeranyl-donor.

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Prostaglandin D₂ ≥98% (by HPLC)

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Prostanoid receptor ligand.

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TRAM 34 ≥98% (by HPLC)

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TRAM-34 is a potent and selective inhibitor of the intermediate-conductance Ca2+-activated potassium channel (IKCa). It displays immunosuppressive activity and inhibits the proliferation of endometrial cancer cells.

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(+)-Himbacine ≥98%, powder

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Muscarinic acetylcholine receptor antagonist.

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Spermine tetrahydrochloride

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Spermine tetrahydrochloride

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TMTH hydrochloride ≥99%

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Cyclic hydroxylamine spin probe for in vivo, intraperitoneal and intravenous injections.

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1-Acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine (ACP)

Supplier: ENZO LIFE SCIENCES

Cell permeable probe for the detection of intracellular oxidative stress.

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Irinotecan hydrochloride trihydrate ≥98% (by HPLC)

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Topoisomerase I inhibitor

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Anti-Proteasome 20S Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences

The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation. The catalytic core of this unusually large (2000kDa, 450Å in length) complex is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. Based on sequence similarity, all fourteen 20S proteasomal subunit sequences may be classified into two groups, α and β, each group having distinct structural and functional roles. The α-subunits comprise the outer rings and the β-subunits the inner rings of the 20S proteasome. Observations of the eukaryotic proteasome and analysis of subunit sequences indicate that each ring contains seven different subunits (α7β7β7α7) with a member of each sub-family represented in each particle. Each subunit is located in a unique position within the α- or β-rings. 120S Proteasomes degrade only unfolded proteins in an energy-independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP-dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome. The hybridoma secreting the antibody to subunits HC2, HC3, HC8, HC9, Iota and Zeta was generated by fusion of spenocytes from Balb/c mice which had recieved repeated immunisation with dinitrophenylated proteasomes.

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Anti-NNOS Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Host: Rabbit

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Anti-PAG1 Rabbit Polyclonal Antibody

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Host: Rabbit

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Human recombinant SET7/9 (from E. coli)

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Produced in E. coli.

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Human recombinant NEDP1 (from E. coli)

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Deconjugating Enzyme (DCE)

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SU 9516 ≥95% (by HPLC)

Supplier: Enzo Life Sciences

Cell permeable, potent, selective and ATP-competitive inhibitor of CDK2/cyclin A (IC50=22nM), CDK1/cyclin B (IC50=40nM) and CDK4/cyclin D1 (IC50=200nM). Has no effect on the activity of PKC, p38, PDGFRβ and EGFR (IC50>10µM). Displays anti-proliferative and pro-apoptotic properties in tumor cells. Inhibits proliferation of growth factor-stimulated colon carcinoma cells by binding to CDK2 and thus preventing the phosphorylation of pRb and its dissociation from E2F.

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NU 2058

Supplier: Enzo Life Sciences

Competitive inhibitor of CDK1/cyclin B (IC50=5µM) and CDK2/cyclin A (IC50=12µM). Pharmacologically distinct from the relative specific inhibitor of CDK1/2 roscovitine.