"Cayman Chemical"

Supplier: Cayman Chemical

BSA-Palmitate saturated fatty acid complex is composed of palmitic acid and bovine serum albumin (BSA) at an approximately 6:1 molar ratio of palmitate:BSA. It can be used for efficient fatty acid delivery to cells in culture for the purpose of monitoring fatty acid oxidation or similar processes in various cellular metabolic studies.

Supplier: Cayman Chemical

Hygromycin B

Supplier: Cayman Chemical

2-Aminopyrazine

Supplier: Cayman Chemical

Leukotoxin is the 9(10) epoxide of linoleic acid, generated by neutrophils during the oxidative burst. This unstable compound is rapidly degraded by epoxide hydrolases to form the diol, (±)9(10)-DiHOME. Mitochondrial dysfunction, vasodilation and apoptosis are features of leukotoxin toxicity. In renal phydrolysesroximal tubular cells, the diol hydrolysis products of leukotoxin, such as (±)9(10)-DiHOME, have been directly implicated as the cytotoxic agent responsible for cell death.

Supplier: Cayman Chemical

iFSP1 is an inhibitor of apoptosis inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1)

Supplier: Cayman Chemical

Ethyl tricosanoate

Supplier: Cayman Chemical

A competitive assay for measurement of enterolactone in plasma, urine, and other biological sample matrices.

Supplier: Cayman Chemical

A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway. Cerulenin also leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.

Supplier: Cayman Chemical

trans,trans-2,4-Decadienal

Supplier: Cayman Chemical

(±)-17-HDoHE

Supplier: Cayman Chemical

Saturated fatty acids are synthesised by both plants and animals from acetyl coenzyme A as a form of long-term energy storage. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of the normal human dietary fat intake, and approximately 25% of the total plasma fatty acids in plasma lipoproteins. Saturated free fatty acids induce the expression of cyclooxygenase-2. Palmitic acid methyl ester (MP) is a fatty acid ester whose concentration in cells is modulated by methanol. In studies with isolated Kupffer cells, MP inhibits phagocytosis and decreases cell viability. In cells treated with lipopolysaccharide, it also decreases secretion of interleukin-10, TNF-α, nitric oxide, and prostaglandin E2. This effect is thought to occur by the inhibition of NF-κB.

Supplier: Cayman Chemical

Natamycin is a naturally-occurring macrolide polyene antifungal agent produced during fermentation by the bacterium S. natalensis, commonly found in soil. Used to treat fungal infections, including candida, aspergillus, cephalosporium, fusarium, and penicillium.

Supplier: Cayman Chemical

Doxorubicin is an anthracycline anti-tumour antibiotic which involves in inhibition of DNA topoisomerase II by inducing double-stranded DNA breaks. It is also involved in the inhibition of nucleic acid synthesis by intercalating within DNA. The accumulation of the p53 tumour suppressor protein leads to the apoptosis in cells.

Supplier: Cayman Chemical

γ-Linolenic acid methyl ester

Supplier: Cayman Chemical

18β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC₅₀ = 35 μM). At 100 mg/kg/day, 18β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats. It inhibits mammalian DNA polymerases α, γ, κ and λ with IC₅₀ values of 16,1, 19,3, 15,8 and 13,7 μM, respectively. At 100-200 μM, 18β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.

Supplier: Cayman Chemical

(S)-17-HDoHE