Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM fo r Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1]. 1 * 5 mg
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