Hard tissue like bones or teeth, and all specimens of calcified tissue like bone marrow punches require special pre-treatment before routine processing by a histological laboratory.

Osteomoll® decalcifies effectively and depending on the size and density of the tissue, can be used twice, provided that the solution is still clear after the first decalcification process.

Osteosoft® is used for gentle decalcification based on complex-forming agents, particularly if it is to be followed by immunohistological procedures.