Human/Mouse/Rat Recombinant BMP-2 (from E. coli)

Bone morphogenetic protein 2 (BMP-2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Active BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7. BMP-2 signals through type I and type II receptor tyrosine kinases in conjuction with SMAD proteins to directly promote osteoblast differentiation. BMP-2 is also important during cardiac development and supports epicardial cell migration.

High quality
Low endotoxin
Affordable

: For research use only.

Conjugation:
Unconjugated
Protein function:
Cytokine
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Human
Rat
Mouse
Storage conditions:
At or below –20 °C
Endotoxin content:
Endotoxin LAL (EU/µg) ≤1
Biological activity:
Bioactivity Assay: Alkaline phosphatase activity induced in ATDC-5 cells, ED₅₀ ≤250 ng/ml, Bioactivity ≥4,0×10³ units/mg
Gene ID:
P12643 / P21274 / P49001
Reconstitution instructions:
Sterile water at 0,1 mg/ml
Endotoxin-free:
N
Carrier-free:
Y
Protease-free:
N
Animal-free:
N
Protein synonyms:
BMP-2A
Protein/peptide name:
H/M/R BMP-2
Purity:
≥95%
Molecular weight:
13,0/26,1 kDa
Sequence:
MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Endotoxin level:
Low
Formulation:
0,1% Trifluoroacetic acid (TFA)
Nuclease-free:
N
Grade:
RUO
Shipping temperature:
RT
Tested applications:
Bioassay