Anti-E-cadherin (CD324) Rat Monoclonal Antibody [clone: DECMA-1]

Supplier: STEMCELL Technologies

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Supplier: STEMCELL Technologies

About this item

Rat monoclonal IgG1 antibody against human, mouse, dog E-cadherin (CD324), unconjugated.

Airway cells

The DECMA-1 antibody recognizes E-cadherin, a calcium-dependent transmembrane glycoprotein involved in cell-cell adhesion, bacterial pathogenesis, and tumor invasion. The extracellular region of E-cadherin is composed of multiple cadherin repeats that contain calcium-binding motifs. The cytoplasmic domain of E-cadherin is reported to interact with a range of intracellular proteins including erbin, ezrin, caspase-3, caspase-8, β-catenin, presenilin 1, and casein kinase II. E-cadherin is expressed in most epithelial cells and in erythroid cells. The E-cadherin antibody is often used as a neutralizing antibody to inhibit E-cadherin-mediated cell-cell interactions.

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Type:
Antigen: E-cadherin (CD324)
Clonality: Monoclonal
Clone: DECMA-1
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG1 kappa
Reactivity: Dog;Human;Mouse;Pig