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Anti-c-Abl Ser569 Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Anti-c-Abl Ser569 Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Catalog # BOSSBS-12904R-A680
Supplier:  Bioss
Anti-c-Abl Ser569 Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Catalog # BOSSBS-12904R-A680
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    c-Abl Ser569
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 680
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human
  • Western blot:
    Yes
  • Environmentally Preferable:
  • Form:
    Liquid
  • Gene ID:
    25
  • Antigen synonyms:
    ABL|Abl 1|JTK 7|Proto oncogene tyrosine protein kinase ABL1|Bcr/c abl oncogene protein|p150 |JTK7|Abelson murine leukemia viral v abl oncogene homolog 1|Transformation gene oncogene ABL|p-c Ablphospho S569|v abl Abelson murine leukemia viral oncogene homolog 1|p-c Ablphospho Ser569|Abl protein|Abl1|c Ablphospho S569|v abl|Abelson Murine Leukemia Viral Oncogene Homolog 1|ABL1_HUMAN
  • Modification:
    Phosphorylation (Ser569)
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Molecular weight:
    123 kDa
  • Storage temperature:
    Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic phosphopeptide derived from human c-Abl isoform a around the phosphorylation site of Ser569
  • Tested applications:
    ICC
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukaemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Type: Primary
Antigen: c-Abl Ser569
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human