Specifications
- Antibody type:Primary
- Antigen name:c-Abl Ser569
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human
- Western blot:Yes
- Environmentally Preferable:
- Form:Liquid
- Gene ID:25
- Antigen synonyms:ABL|Abl 1|JTK 7|Proto oncogene tyrosine protein kinase ABL1|Bcr/c abl oncogene protein|p150 |JTK7|Abelson murine leukemia viral v abl oncogene homolog 1|Transformation gene oncogene ABL|p-c Ablphospho S569|v abl Abelson murine leukemia viral oncogene homolog 1|p-c Ablphospho Ser569|Abl protein|Abl1|c Ablphospho S569|v abl|Abelson Murine Leukemia Viral Oncogene Homolog 1|ABL1_HUMAN
- Modification:Phosphorylation (Ser569)
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:123 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic phosphopeptide derived from human c-Abl isoform a around the phosphorylation site of Ser569
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukaemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
Type: Primary
Antigen: c-Abl Ser569
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human