- Antibody type:Primary
- Antigen name:Histone H3
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitope:71-136/136
- Form:Liquid
- Gene ID:3020
- Antigen synonyms:H3FA|HIST1H3J|H3FJ|H3F2|HIST1H3E|HIST1H3G|H3.3B|HIST1H3B|H3.3A|H3FI|H3.1|HIST1H3D|H3.2|H3FM|HIST2H3A|HIST1H3C|HIST1H3I|HIST1H3F|H3F3A|PP781|H3F3C|HIST3H3|H3FH|HIST2H3D|H3FD|H3.5|H3.3C|H3FF|H3.1t|Histone H3|HIST1H3H|H3F3B|H3FC|H3FB|H3FT|H3FL|H3F3|HIST2H3C|H3.3|H3FK|HIST1H3A
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:15 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human Histone H3
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling.
Type: Primary
Antigen: Histone H3
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 71-136/136
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Others