- Antibody type:Primary
- Antigen name:Tie2 Tyr992
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human
- Western blot:Yes
- Form:Liquid
- Gene ID:7010
- Antigen synonyms:hTIE2|Tie-2|hTIE 2|TEK tyrosine kinase endothelial|Venous malformations multiple cutaneous and mucosal|tek tyrosine kinase|p140 TEK|VMCM|Angiopoietin 1 receptor|Tunica interna endothelial cell kinase|Tyrosine kinase with Ig and EGF homology domains 2|Tyrosine protein kinase receptor TIE 2|Angiopoietin-1 receptor|tek tyrosine kinase, endothelial|CD202b antigen|Endothelium specic receptor tyrosine kinase 2|Tie2|Hyk|Tyrosine-protein kinase receptor TIE-2|Soluble TIE2 variant 1|Tyrosine-protein kinase receptor TEK|Soluble TIE2 variant 2|Tek|TIE2_HUMAN|VMCM 1|Endothelial tyrosine kinase|Tyrosine protein kinase receptor TEK|TIE 2|VMCM1|CD202b
- Modification:Phosphorylation (Tyr992)
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:124 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic phosphopeptide derived from human Tie2 around the phosphorylation site of Tyr992
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.TEK is closely related to the TIE receptor tyrosine kinase.
Type: Primary
Antigen: Tie2 Tyr992
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human