Human Recombinant IL-1B (Animal free) (from E. coli)

Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter.

High quality
Low endotoxin
Affordable

IL-1β and the independently regulated IL-1α protein have overlapping pro-inflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

: A certificate of analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.

: For research use only.

Protein function:
Cytokine
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Human
Storage conditions:
−20 °C
Biological activity:
D10S cell proliferation at less than or equal to 12 pg/ml or (8,3×10⁷ units/mg specific units)
Reconstitution instructions:
Reconstitute with sterile water at 0,1 mg/ml
Animal-free:
Y
Protein synonyms:
EP|Catabolin|LAF|LEM|MCF
UniProtKB:
P01584
Protein/peptide name:
IL-1 beta
Purity:
>95%
Molecular weight:
17.5 kDa (monomer)
Sequence:
MAPVRSLNCT LRDSQQKSLV MSGPYELKAL HLQGQDMEQQ VVFSMSFVQG EESNDKIPVA LGLKEKNLYL SCVLKDDKPT LQLESVDPKN YPKKKMEKRF VFNKIEINNK LEFESAQFPN WYISTSQAEN MPVFLGGTKG GQDITDFTMQ FVSS
Endotoxin level:
≤1 EUs/μg
Formulation:
Lyophilised from a sterile (0,2 µm) filtered aqueous solution containing 10 mM sodium phosphate, pH 7,5
Shipping temperature:
Ambient
Tested applications:
Bioassay
Conjugation:
Unconjugated
Endotoxin content:
Endotoxin LAL (EU/µg) ≤1
Gene ID:
P01584
Endotoxin-free:
N
Carrier-free:
Y
Protease-free:
N
Nuclease-free:
N
Grade:
RUO