HALO® HPLC and UHPLC columns are based on innovative Fused-Core particle technology. These particles are formed from a solid core and porous outer shell. HALO® columns provide high efficiencies and separation speeds but at approximately half the back pressure for the same column length. This lower pressure means that HALO® columns can be used with conventional HPLC and LC-MS systems, as well as with UHPLC systems.

• Ultra-fast separations
• High resolution and high efficiency
• Lower backpressure than fully-porous HPLC columns
• UHPLC like separation using HPLC instruments
• Excellent ruggedness and reproducibility

The HALO® 400 Å C4 is suitable for the analysis of large biomolecules, including monoclonal antibodies and their various antibody-drug conjugates (ADCs).