Human recombinant ABL1, HIS-tag
Catalog # ENZOBMLSE5620005
Supplier: ENZO LIFE SCIENCES
CAS Number:
Specifications
- Pk:5 µG
- Protein/peptide type:Recombinant
- Species:Human
- Seq:02
- Tag sequence:HIS Tag
- Protein/peptide name:ABL1
- Purity:>70% (SDS-PAGE)
- Concentration:0,1 mg/ml
- Formulation:Liquid. In 50 mM TRIS-HCl, pH 7,5, containing 150 mM sodium chloride, 0,25 mM DTT, 0,1 mM EGTA, 0,1 mM EDTA, 0,1 mM PMSF and 25% glycerol.
Specifications
About this item
Produced in insect cells.
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in cell differentiation, cell division, cell adhesion, and stress responses. The c-Abl protein is inhibited by its SH3 domain, and deletion of this domain turns ABL1 into an oncogene. A chromosomal translocation results in the head-to-tail fusion of the BCR and ABL1 genes. This translocation is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of Abl1 is regulated by CDC2-mediated phosphorylation.