PROTEOSTAT® Protein aggregation assay provides a simple, homogenous assay format for monitoring peptide and protein aggregation in solution. This is useful for defining optimal storage formulations for proteins, for screening of compounds that promote or inhibit protein aggregation and potentially for the sensitive measurement of molecular chaperone activity. The assay can be employed to streamline protein processing and formulation optimization procedures.

• Validated for use with microplate or flow cytometry platform
• Extensively benchmarked with IgG
• Optimize buffers and excipients for protein formulation
• Performs with a wide pH and ionic strength range
• Quantitative detection of protein aggregates from visible to subvisible particles

The assay is capable of providing quantitative analysis of protein aggregation in a robust and high-throughput fashion (Z’ factor score >0,5). Lyophilised native and aggregated protein are provided as negative and positive controls for monitoring changes in protein aggregation status.

This is useful for defining optimal storage formulations for proteins, for screening of compounds that promote or inhibit protein aggregation and potentially for the sensitive measurement of molecular chaperone activity. The assay can be employed to streamline protein processing and formulation optimisation procedures.