- Pk:25 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Tag sequence:His Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein synonyms:CD137 Antigen|Tumor Necrosis Factor Receptor Superfamily Member 9|T Cell Antigen ILA|TNFRSF9|MGC2172|ILA|CDw137|4-1BB|4-1BB Ligand Receptor T Cell|Antigen 4-1BB Homolog
- Protein/peptide name:CD137
- Purity:>95% (SDS-PAGE)
- Sequence:19-184
- Formulation:Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl.
Human CD137 (4-1BB) is a costimulatory molecule of the tumour necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumour receptor-associated factors (TRAF), the adaptor protein and mediates downstream signalling events including the activation of NF-kappaB and cytokine production. 4-1BB signalling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumour immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.
Fusion-Tag: His Tag
This recombinant proteins is for research use only.