Human Recombinant EIF4E-Binding 1 (from E. coli)
Catalog # PRSI91-180
Supplier: ProSci Inc.
CAS Number:
Specifications
- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Tag sequence:N-6 His tag
- Storage conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Protein synonyms:eIF4E-Binding Protein 1|PHAS-I|EIF4EBP1|Eukaryotic Translation Initiation Factor 4E-Binding Protein 1|Phosphorylated Heat- and Acid-Stable Protein Regulated by Insulin 1|4E-BP1
- Protein/peptide name:EIF4E-Binding 1
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:14.74 kD
- Sequence:Met1-Ile118
- Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:For Biological assays
Specifications
About this item
Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) is a number of the eIF4E-binding protein family. 4EBP1 regulates eIF4E activity by preventing its assembly into the eIF4F complex. 4EBP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Non-phosphorylated 4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E. 4EBP1 is phosphorylated in response to various signals including insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. 4EBP1 has a role in progression of breast neoplasms through cell signaling.
- This recombinant protein can be used for biological assays. For research use only.
Fusion-Tag: N-6 His tag