Specifications
- Pk:20 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Biological activity:The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is = 0.2 ng/mL, corresponding to a specific activity of = 5 x 106 units/mg.
- Protein synonyms:BCGF-1|B-cell stimulatory factor 1|IL-4|BCGF1|BSF1|BSF-1|Interleukin-4
- Protein/peptide name:IL4
- Purity:>98%
- Formulation:Lyophilized
Specifications
About this item
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues. Recombinant rat IL-4 is a 14.0 kDa globular protein containing 126 amino acid residues. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 120 amino acid residues.
- Store in working aliquots at -20°C. Avoid freeze/thaw cycles.