Anti-KEAP1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
BOSSBS-3648R-FITC
: Bioss
- Antibody type:Primary
- Antigen name:Kelch-like ECH-associated protein 1
- Antigen symbol:KEAP1
- Clonality:Polyclonal
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Environmentally Preferable:
- Cross adsorption:No
- Form:liquid
- Gene ID:9817
- Antigen synonyms:KLHL19|KIAA0132|Cytosolic inhibitor of Nrf2|KEAP1|Kelch-like ECH-associated protein 1|INRF2|INrf2
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:75-125/624
- Purification:Purified by Protein A
- Pk:100 µl
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: KEAP1
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat