About this item
This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk's and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
Type: Primary
Antigen: CDKN1A
Clonality: Monoclonal
Clone: CIP1/823 DCS-60.2
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgGs
Reactivity: Human
Specifications
- Catalog No:
- BNCB1135-100
- BNCB1135-500
- Antigen symbol:
- CDKN1A
- CDKN1A
- Antigen name:
- Cyclin-dependent kinase inhibitor 1A
- Cyclin-dependent kinase inhibitor 1A
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- Biotin
- Biotin
- Clone:
- Clone CIP1/823 DCS-60.2
- Clone CIP1/823 DCS-60.2
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 370771
- 370771
- Isotype:
- IgGs
- IgGs
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Supplier: VWR Chemicals
Supplier: VWR Chemicals
Supplier: VWR Collection
Supplier: KIMBERLY CLARK
Supplier: HEATHROW
Supplier: VWR Chemicals
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Chemicals
Supplier: VWR Collection
Supplier: Merck