ISOLUTE® NH₂ is a non-polar and non-endcapped sorbent, manufactured using a trifunctional silane.

These sorbents can be used either as a polar phase conditioned with a non-polar solvent can hydrogen bond with any molecule containing an -OH, -NH or -SH functional group or a weak anion exchanger in aqueous environment because all the -NH₂ groups are protonated and the column can retain molecules that carry a negative charge.