You searched for: CHIR99021

Supplier: Apollo Scientific

CHIR99021 free base ≥99%

Supplier: Abcam

Potent, highly selective aminopyrimidine GSK3 inhibitor (IC₅₀ values are 6,7 and 10 nM at GSK3β and GSK3α, respectively). Exhibits >500-fold selectivity for GSK3 against 20 closely related protein kinases and >800-fold selectivity for 23 additional enzymes and 22 receptors. Promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization. Commonly used in multiple stages of organoid generation.

Supplier: Thermo Fisher Scientific

Chemical probes can be used to help establish the
relationship between a molecular target and the broader
biological consequences of modulating that target in cells
or organisms.