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Clotrimazole

Clotrimazole

Supplier: Thermo Fisher Scientific

Clotrimazole

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Clotrimazole

Supplier: Thermo Fisher Scientific

Clotrimazole

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Clotrimazole ≥98.0% (by TLC), Sigma-Aldrich®

Supplier: Merck

Clotrimazole is a specific inhibitor of Ca²⁺ activated K⁺ channels. It is an antifungal azole. Clotrimazole is a derivative of imidazole and has similar antimicrobial action and activity to ketoconazole. It inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.

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