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Anti-AVEN Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Anti-AVEN Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-2438R-A750
Supplier:  Bioss
Anti-AVEN Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-2438R-A750
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    AVEN
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 750
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Western blot:
    Yes
  • Epitope:
    301-362/362
  • Form:
    Liquid
  • Gene ID:
    57099
  • Antigen synonyms:
    1700056A21Rik|RP23-52C15.2|Programmed cell death 12|MGC124011|mAven L|1700013A01Rik|AVEN_HUMAN|Apoptosis caspase activation inhibitor|OTTMUSP00000016129|mAven S|PDCD12|Cell death regulator Aven
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Molecular weight:
    38 kDa
  • Storage temperature:
    Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human AVEN
  • Tested applications:
    ICC
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukaemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukaemia patients.

Type: Primary
Antigen: AVEN
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 301-362/362
Host: Rabbit
Isotype: IgG
Reactivity:

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