Anti-BBS9 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog # BOSSBS-11511R-A750

Supplier: Bioss

Catalog # BOSSBS-11511R-A750

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
BBS9
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 750
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Rat
Epitope:
244-320/887
Form:
Liquid
Gene ID:
27241
Antigen synonyms:
Parathyroid hormone-responsive B1 gene protein|BBS9|PTHB1|Protein PTHB1|D1|C18|B1|Bardet-Biedl syndrome 9 protein
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
99 kDa
Storage temperature:
Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human BBS9
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Specifications

About this item

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localisation.

Type: Primary
Antigen: BBS9
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 244-320/887
Host: Rabbit
Isotype: IgG
Reactivity: Rat