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2828 results for "TONBO BIOSCIENCE"

2828 Results for: "TONBO BIOSCIENCE"

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Anti-IgG Donkey Polyclonal Antibody (HRP (Horseradish Peroxidase))

Supplier: TONBO BIOSCIENCE

Donkey anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate

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Anti-IgG Goat Polyclonal Antibody (HRP (Horseradish Peroxidase))

Supplier: TONBO BIOSCIENCE

Goat anti-Rat IgG (H&L) - Affinity Pure, HRP Conjugate

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Anti-IgM Goat Polyclonal Antibody

Supplier: TONBO BIOSCIENCE

Goat anti-Human IgM (mu chain) - Affinity Pure, min x w/human IgG; bovine, goat, mouse or rabbit serum proteins

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Anti-IgA Goat Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: TONBO BIOSCIENCE

Goat anti-Human IgA (alpha chain), F(ab')2 Fragment - Affinity Pure, FITC Conjugate

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Anti-IgA Goat Polyclonal Antibody (Biotin)

Supplier: TONBO BIOSCIENCE

Goat anti-Human IgA (alpha chain), F(ab)'2 Fragment - Affinity Pure, Biotin Conjugate

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Anti-MHC Class II (I-A/I-E) Rat Monoclonal Antibody (APC-Cyanine7) [clone: M5/114.15.2]

Anti-MHC Class II (I-A/I-E) Rat Monoclonal Antibody (APC-Cyanine7) [clone: M5/114.15.2]

Supplier: TONBO BIOSCIENCE

The M5/114.15.2 antibody reacts with mouse MHC Class II alloantigens I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek, as well as being cross-reactive with mouse cells of H-2p and H-2r haplotype. MHC Class II is widely expressed by mouse immune cells bearing these alloantigens, including T and B cells, monocytes, macrophages, and dendritic cells. The antibody does not react with the following alloantigens: I-Af, I-Ak, I-As, or NOD H-2g7. The M5/114.15.2 antibody may be used for analysis of mouse cells expressing MHC Class II alloantigens as described. Please note that the M5/114.15.2 clone may also be referred to as M5/114 in the literature.

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Anti-HLA-DR Mouse Monoclonal Antibody (PerCP) [clone: L243]

Anti-HLA-DR Mouse Monoclonal Antibody (PerCP) [clone: L243]

Supplier: TONBO BIOSCIENCE

The L243 antibody reacts with a member of the human MHC Class II antigens, HLA-DR. The HLA-DR antigen is expressed on B lymphocytes, activated T lymphocytes, activated NK cells, monocytes, macrophages, other antigen presenting cells and progenitor cells. The L243 antibody is specific to an epitope on the alpha subunit of the heterodimeric HLA-DR protein and binds a different epitope than the LN3 antibody clone. It does not cross-react with HLA-DP or HLA-DQ. This antibody is reported to be cross-reactive with non-human primates including Chimpanzee, Cynomolgus, Rhesus and Baboon. Please choose the appropriate format for each application.

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Anti-HLA-DR Mouse Monoclonal Antibody (APC-Cyanine7) [clone: L243]

Anti-HLA-DR Mouse Monoclonal Antibody (APC-Cyanine7) [clone: L243]

Supplier: TONBO BIOSCIENCE

The L243 antibody reacts with a member of the human MHC Class II antigens, HLA-DR. The HLA-DR antigen is expressed on B lymphocytes, activated T lymphocytes, activated NK cells, monocytes, macrophages, other antigen presenting cells and progenitor cells. The L243 antibody is specific to an epitope on the alpha subunit of the heterodimeric HLA-DR protein and binds a different epitope than the LN3 antibody clone. It does not cross-react with HLA-DP or HLA-DQ. This antibody is reported to be cross-reactive with non-human primates including Chimpanzee, Cynomolgus, Rhesus and Baboon. Please choose the appropriate format for each application.

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Anti-CD20 Mouse Monoclonal Antibody (APC-Cyanine7) [clone: 2H7]

Anti-CD20 Mouse Monoclonal Antibody (APC-Cyanine7) [clone: 2H7]

Supplier: TONBO BIOSCIENCE

The 2H7 antibody reacts with human CD20, expressed by pre-B cells, resting and activated B cells, follicular dendritic cells and a small subset of T cells, but not on plasma cells. CD20 is a 33-37 kDa transmembrane protein which is differentially phosphorylated in resting and active B cells. The CD20 molecule plays a role in regulating B-cell activation. The 2H7 antibody is reported to be cross-reactive with several non-human species including Baboon, Chimpanzee, Cynomolgus and Rhesus. Please choose the appropriate format for each application.

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Anti-CD252 (OX40 Ligand) Rat Monoclonal Antibody (APC (Allophycocyanine)) [clone: RM134L]

Supplier: TONBO BIOSCIENCE

The RM134L antibody recognizes CD252, also known as OX-40 Ligand or CD134 Ligand, a member of the TNF superfamily that is present on the surface of antigen presenting cells and activated B lymphocytes. The OX-40 Ligand interacts with OX-40 (CD134) which is expressed primarily on activated T cells. This costimulatory interaction leads to increased proliferation and IL-2 production responses of activated T cells, and at the same time enhances proliferation and immunoglobulin secretion by activated B cells.

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Anti-ITGAM Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: ICRF44]

Anti-ITGAM Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: ICRF44]

Supplier: TONBO BIOSCIENCE

The ICRF44 antibody reacts with human CD11b, also known as integrin alpha M. This 165 to 170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1, ICAM-2, ICAM-3 and ICAM-4 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

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Anti-IL2RA Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: PC61.5]

Anti-IL2RA Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: PC61.5]

Supplier: TONBO BIOSCIENCE

The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells.

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Anti-ITGAX Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: 3.9]

Anti-ITGAX Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: 3.9]

Supplier: TONBO BIOSCIENCE

The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

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Anti-CD8A Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: 53-6.7]

Anti-CD8A Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: 53-6.7]

Supplier: TONBO BIOSCIENCE

The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

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Anti-CD27 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: O323]

Anti-CD27 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: O323]

Supplier: TONBO BIOSCIENCE

The O323 antibody reacts with human CD27 (TNFRSF7), a cell surface homodimer of 55 kDa subunits, which provides co-stimulatory signaling in support of the T cell (TCR) and B cell (BCR) receptors. By comparison with CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling appears to promote cell survival and differentiation to effector / memory stages. Also in contrast with CD28, the CD27 receptor may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells and B cells. With respect to B cells, CD27 is considered to be a phenotypic marker for memory B cells. CD27 has been included within a group of phenotypic markers for identifying human B regulatory cells (Bregs), a cell type proposed to regulate CD4+ T cell proliferation and Foxp3 / CTLA-4 expression in Treg cells.

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Anti-CD4 Rat Monoclonal Antibody (PE (Phycoerythrin)/Cy5®) [clone: GK1.5]

Supplier: TONBO BIOSCIENCE

The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells

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Anti-FCER1 Armenian Hamster monoclonal antibody [clone: MAR-1]

Anti-FCER1 Armenian Hamster monoclonal antibody [clone: MAR-1]

Supplier: TONBO BIOSCIENCE

The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.

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Anti-KLRG1 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: 2F1]

Anti-KLRG1 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: 2F1]

Supplier: TONBO BIOSCIENCE

The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).

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Anti-IFNG Rat Monoclonal Antibody (FITC (Fluorescein)) [clone: XMG1.2]

Anti-IFNG Rat Monoclonal Antibody (FITC (Fluorescein)) [clone: XMG1.2]

Supplier: TONBO BIOSCIENCE

The XMG1.2 antibody is specific for mouse Interferon-gamma (IFN-g), a 20 kDa type II cytokine known for its central roles in protection against bacterial or viral pathogens and for its anti-tumor properties. IFN-g is secreted by several types of immune cells, which allow the cytokine to modulate innate immunity, when secreted by NK and NKT cells, and to function in supporting adaptive immunity when secreted by Th1 and CD8+ T cells (CTLs).

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Anti-CSF1R Rat Monoclonal Antibody (FITC (Fluorescein)) [clone: AFS98]

Anti-CSF1R Rat Monoclonal Antibody (FITC (Fluorescein)) [clone: AFS98]

Supplier: TONBO BIOSCIENCE

The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerisation of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.

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Anti-CD8A Rat Monoclonal Antibody [clone: 53-6.7]

Anti-CD8A Rat Monoclonal Antibody [clone: 53-6.7]

Supplier: TONBO BIOSCIENCE

The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

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Anti-FCGR2/3 Rat monoclonal antibody [clone: 2.4G2]

Supplier: TONBO BIOSCIENCE

The 2.4G2 antibody is specific for a common epitope found in the extracellular regions of mouse Fc-receptors Fc-gamma II (CD32) and Fc-gamma III (CD16). As these are receptors for the Fc portion of mouse IgG, they may also bind laboratory antibody preparations and products used in a variety of cell analysis protocols such as flow cytometry, immunohistochemistry and functional cell assays. The 2.4G2 antibody is therefore widely used as a pre-treatment reagent to block binding of specific antibodies of interest, e.g. fluorescently conjugated antibodies, to Fc receptors via their Fc domains and contributing to “non-specific” staining.

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Anti-MHC II (I-A/I-E) Rat Monoclonal Antibody (FITC (Fluorescein)) [clone: M5/115.15.2]

Anti-MHC II (I-A/I-E) Rat Monoclonal Antibody (FITC (Fluorescein)) [clone: M5/115.15.2]

Supplier: TONBO BIOSCIENCE

The M5/114.15.2 antibody reacts with mouse MHC Class II alloantigens I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek, as well as being cross-reactive with mouse cells of H-2p and H-2r haplotype. MHC Class II is widely expressed by mouse immune cells bearing these alloantigens, including T and B cells, monocytes, macrophages and dendritic cells. The antibody does not react with the following alloantigens: I-Af, I-Ak, I-As, or NOD H-2g7.

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Anti-IL7R Rat Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: A7R34]

Anti-IL7R Rat Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: A7R34]

Supplier: TONBO BIOSCIENCE

The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.

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Anti-CD28 Mouse Monoclonal Antibody [clone: 37.51]

Anti-CD28 Mouse Monoclonal Antibody [clone: 37.51]

Supplier: TONBO BIOSCIENCE

The 37.51 antibody reacts with mouse CD28, a 45 kDa glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction/co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of co-stimulatory receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.

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Anti-ITGAX Armenian Hamster Monoclonal Antibody [clone: N418]

Anti-ITGAX Armenian Hamster Monoclonal Antibody [clone: N418]

Supplier: TONBO BIOSCIENCE

The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

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Anti-CD8A Rat Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: 2.43]

Anti-CD8A Rat Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: 2.43]

Supplier: TONBO BIOSCIENCE

The 2.43 antibody reacts with the 32 to 34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death in tumor cells, as well as in cells infected by virus, bacteria or parasites.

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Rat IgG1 Isotype Control [clone: HRPN] (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®)

Rat IgG1 Isotype Control [clone: HRPN] (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®)

Supplier: TONBO BIOSCIENCE

The HRPN immunoglobulin is useful as an isotype-matched control. The HRPN immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG1 antibodies.

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Anti-CD28 Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: CD28.2]

Anti-CD28 Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: CD28.2]

Supplier: TONBO BIOSCIENCE

The CD 28,2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction/co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.

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Anti-CD27 Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: O323]

Anti-CD27 Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: O323]

Supplier: TONBO BIOSCIENCE

The O323 antibody reacts with human CD27 (TNFRSF7), a cell surface homodimer of 55 kDa subunits, which provides co-stimulatory signaling in support of the T cell (TCR) and B cell (BCR) receptors. By comparison with CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling appears to promote cell survival and differentiation to effector / memory stages. Also in contrast with CD28, the CD27 receptor may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells and B cells. With respect to B cells, CD27 is considered to be a phenotypic marker for memory B cells. CD27 has been included within a group of phenotypic markers for identifying human B regulatory cells (Bregs), a cell type proposed to regulate CD4+ T cell proliferation and Foxp3 / CTLA-4 expression in Treg cells.

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