42851 Results for: "PROSCI"
Anti-H3.1 Rabbit Polyclonal Antibody
Supplier: PROSCI
Anti-H3.1 Rabbit Polyclonal Antibody
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Anti-MEOX2 Mouse Monoclonal Antibody
Supplier: PROSCI
Anti-MEOX2 Mouse Monoclonal Antibody
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Anti-BAD Rabbit Polyclonal Antibody
Supplier: PROSCI
The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
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Anti-ERBB2 Rabbit Polyclonal Antibody
Supplier: PROSCI
Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.
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Anti-JAK1 Rabbit Polyclonal Antibody
Supplier: PROSCI
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
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Anti-CHUK Rabbit Polyclonal Antibody
Supplier: PROSCI
Acts as part of the IKK complex in the conventional pathway of NF-κ-B activation and phosphorylates inhibitors of NF-κ-B thus leading to the dissociation of the inhibitor/NF-κ-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-κ-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-κ-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-κ-B-regulated promoters during inflammatory responses triggered by cytokines.
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Anti-APBB2 Rabbit Polyclonal Antibody
Supplier: PROSCI
Anti-APBB2 Rabbit Polyclonal Antibody
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Anti-RCC1 Rabbit Polyclonal Antibody
Supplier: PROSCI
Anti-RCC1 Rabbit Polyclonal Antibody
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Anti-SOD1 Rabbit Polyclonal Antibody
Supplier: PROSCI
Anti-SOD1 Rabbit Polyclonal Antibody
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Anti-OPTN Rabbit Polyclonal Antibody
Supplier: PROSCI
Anti-OPTN Rabbit Polyclonal Antibody
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Anti-CASR Rabbit Polyclonal Antibody
Supplier: PROSCI
Anti-CASR Rabbit Polyclonal Antibody
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Anti-STAT5B Mouse Monoclonal Antibody
Supplier: PROSCI
Anti-STAT5B Mouse Monoclonal Antibody
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Anti-SMARCD2 Mouse Monoclonal Antibody
Supplier: PROSCI
Anti-SMARCD2 Mouse Monoclonal Antibody
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Anti-TIMP2 Mouse Monoclonal Antibody
Supplier: PROSCI
Anti-TIMP2 Mouse Monoclonal Antibody
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Anti-TSG101 Mouse Monoclonal Antibody
Supplier: PROSCI
Anti-TSG101 Mouse Monoclonal Antibody
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Anti-RELA Rabbit Polyclonal Antibody
Supplier: PROSCI
NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-κ-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-κ-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-κ-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-κ-B complex which translocates to the nucleus. NF-κ-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-κ-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-κ-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-κ-B complex
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Anti-CTNNB1 Rabbit Polyclonal Antibody
Supplier: PROSCI
Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.
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Anti-STMN1 Rabbit Polyclonal Antibody
Supplier: PROSCI
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear
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Anti-PRKCQ Rabbit Polyclonal Antibody
Supplier: PROSCI
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-κ-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
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Anti-QSOX2 Rabbit Polyclonal Antibody
Supplier: PROSCI
Anti-QSOX2 Rabbit Polyclonal Antibody
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Anti-RPS6KA5 Rabbit Polyclonal Antibody
Supplier: PROSCI
Anti-RPS6KA5 Rabbit Polyclonal Antibody
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Anti-SLC39A6 Rabbit Polyclonal Antibody
Supplier: PROSCI
Anti-SLC39A6 Rabbit Polyclonal Antibody
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Anti-SLITRK6 Rabbit Polyclonal Antibody
Supplier: PROSCI
Anti-SLITRK6 Rabbit Polyclonal Antibody
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Anti-PGR Rabbit Polyclonal Antibody
Supplier: PROSCI
Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.
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Anti-VDR Rabbit Polyclonal Antibody
Supplier: PROSCI
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
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Anti-RELA Rabbit Polyclonal Antibody
Supplier: PROSCI
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex.
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Anti-CDK2 Rabbit Polyclonal Antibody
Supplier: PROSCI
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus.
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Anti-ST8SIA1 Chicken Polyclonal Antibody
Supplier: PROSCI
FUNCTION: Involved in the production of GD3 and GT3 from GM3.
CATALYTIC ACTIVITY: CMP-N-acetylneuraminate + beta-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + beta-N-acetylneuraminyl-2,8-beta-N-acetylneuraminyl-2,3-beta-D-galactosyl-R.
SIMILARITY: Belongs to the glycosyltransferase 29 family.
PATHWAY: Glycosylation.
SUBCELLULAR LOCATION: Golgi apparatus; Golgi membrane; single-pass type II membrane protein
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Anti-SLC7A9 Chicken Polyclonal Antibody
Supplier: PROSCI
FUNCTION: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule.
DISEASE: Defects in SLC7A9 are a cause of non-type I cystinuria (CSNU) [MIM:600918]. CSNU arises from impaired transport of cystine and dibasic amino acids through the epithelial cells of the renal tubule and gastrointestinal tract. Three types of cystinuria have been described: type I (fully recessive or silent); type II (high excretor); type III (moderate excretor). Defects in SLC7A9 are associated with type II and type III cystinuria. They also might account for some non-classic type I cystinuria cases.
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Anti-SGTA Chicken Polyclonal Antibody
Supplier: PROSCI
FUNCTION: Cochaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
SUBUNIT: Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1.
SIMILARITY: Contains 3 TPR repeats.TISSUE SPECIFICITY: Ubiquitous.