2860 Results for: "Tonbo Biosciences"
Anti-CD2 Rat Antibody (PE (Phycoerythrin)) [clone: RM2-5]
Supplier: Tonbo Biosciences
The RM2-5 antibody reacts with mouse CD2, an approximately 50 kDa glycoprotein, and a member of the Ig superfamily. CD2, also known as LFA-2, is a receptor for CD48 in the mouse and is expressed on the cell surface of all mouse lymphocytes. CD2 mediates adhesion between cells and is involved in T cell activation.
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Anti-CD8a Rat Antibody (redFluor™ 710) [clone: 53-6.7]
Supplier: Tonbo Biosciences
The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
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Anti-CD20 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: 2H7]
Supplier: Tonbo Biosciences
The 2H7 antibody reacts with human CD20, expressed by pre-B cells, resting and activated B cells, follicular dendritic cells and a small subset of T cells, but not on plasma cells. CD20 is a 33-37 kDa transmembrane protein which is differentially phosphorylated in resting and active B cells. The CD20 molecule plays a role in regulating B-cell activation.
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Anti-CD4 Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: SK3]
Supplier: Tonbo Biosciences
The SK3 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The SK3 antibody is widely used as a phenotypic marker for human CD4 expression, and has been reported to be cross-reactive with Rhesus and Cynomolgus CD4. This antibody does not block binding of alternative clone RPA-T4, suggesting that they recognize different epitopes.
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Anti-CD20 Mouse Monoclonal Antibody (redFluor® 710) [clone: 2H7]
Supplier: Tonbo Biosciences
The 2H7 antibody reacts with human CD20, expressed by pre-B cells, resting and activated B cells, follicular dendritic cells and a small subset of T cells, but not on plasma cells. CD20 is a 33-37 kDa transmembrane protein which is differentially phosphorylated in resting and active B cells. The CD20 molecule plays a role in regulating B-cell activation.
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Anti-CD56 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: MY31]
Supplier: Tonbo Biosciences
The MY31 antibody reacts with human CD56, also known as the neural cell adhesion molecule (NCAM), a glycoprotein which is a member of the immunoglobulin superfamily. The 140 kDa isoform of CD56 is expressed on human NK cells and NK-T cells, with increased expression levels on activated NK lymphocytes. The CD56 antigen is also expressed by neurons and is reported to play a role in nervous system development and neural cell-to-cell adhesion.
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Anti-CD27 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: O323]
Supplier: Tonbo Biosciences
The O323 antibody reacts with human CD27 (TNFRSF7), a cell surface homodimer of 55 kDa subunits, which provides co-stimulatory signaling in support of the T cell (TCR) and B cell (BCR) receptors. By comparison with CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling appears to promote cell survival and differentiation to effector / memory stages. Also in contrast with CD28, the CD27 receptor may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells and B cells. With respect to B cells, CD27 is considered to be a phenotypic marker for memory B cells. CD27 has been included within a group of phenotypic markers for identifying human B regulatory cells (Bregs), a cell type proposed to regulate CD4+ T cell proliferation and Foxp3 / CTLA-4 expression in Treg cells.
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Anti-TER-119 Rat Monoclonal Antibody (redFluor™ 710) [clone: TER-119]
Supplier: Tonbo Biosciences
The TER-119 antibody is named for the antigen to which it binds, a 52 kDa surface protein that is associated with glycophorin-A. TER-119 is considered to be a lineage marker for later stages of erythroid cell development, as its expression begins at the pro-erythroblast stage. TER-119 antigen is not expressed at either BFU-E or CFU-E stages, i.e. prior to the pro-erythroblast stage.
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Anti-CD62L (L-Selectin) Rat Monoclonal Antibody (redFluor™ 710) [clone: MEL-14]
Supplier: Tonbo Biosciences
The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte 'rolling' on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin family of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research.
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Anti-Ly-6G Rat Monoclonal Antibody (redFluor™ 710) [clone: 1A8]
Supplier: Tonbo Biosciences
The 1A8 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.
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Anti-CD3, CD11b, CD45/B220, Ly-6G, TER-119 Rat Monoclonal Antibody (FITC) [clone: 17A2, M1/70, RA3-6B2, RB6-8C5, TER-119]
Supplier: Tonbo Biosciences
The FITC Mouse Lineage Cocktail contains a combination of pre-diluted antibodies that identify lineage committed cells by flow cytometry and facilitate their exclusion from hematopoietic progenitor cells in mouse bone marrow. The antibodies in the cocktail react with cells from major hematopoietic lineages including T, B and NK cells, monocytes/macrophages, granulocytes and erythrocytes. The Lineage Cocktail contains the following FITC conjugated antibodies: anti-mouse CD3 (17A2), anti-mouse CD11b (M1/70), anti-mouse CD45/B220 (RA3-6B2), anti-mouse Ly-6G (Gr-1) (RB6-8C5) and anti-mouse TER-119 (TER-119). An Isotype Control Cocktail consisting of FITC conjugated isotype-matched control antibodies (Rat IgG2a, kappa; Rat IgG2b, kappa) is also provided in a separate vial.
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Anti-CD45RA Mouse Monoclonal Antibody [clone: HI100]
Supplier: Tonbo Biosciences
The HI100 antibody reacts with the human CD45 isoform known as CD45RA, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RB, CD45RO and others.
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Anti-CD45 Mouse Monoclonal Antibody (PerCP) [clone: 2D1]
Supplier: Tonbo Biosciences
The 2D1 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, and CD45RO.
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Anti-IL-4 Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: MP4-25D2]
Supplier: Tonbo Biosciences
The MP4-25D2 antibody is specific for human IL-4, a pleiotropic cytokine that Th2 cell differentiation, B cell proliferation and differentiation, and B cell class switching to IgE. MP4-25D2 is a neutralizing antibody and is reported to cross react with rhesus monkey IL-4.
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Anti-CD279 (PD-1) Armenian Hamster Monoclonal Antibody (In Vivo Ready™) [clone: J43.1]
Supplier: Tonbo Biosciences
The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with 'B7' ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.
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Anti-IgG Goat Polyclonal Antibody
Supplier: Tonbo Biosciences
Goat anti-Mouse IgG (H&L) - Affinity Pure, min x w/bovine, horse, human, pig or rabbit serum protein
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Anti-IgG Goat Polyclonal Antibody
Supplier: Tonbo Biosciences
Goat anti-Mouse IgG (H&L) - Affinity Pure, min x w/bovine, goat, human, rabbit or rat IgG
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Anti-IgG Goat Polyclonal Antibody (Biotin)
Supplier: Tonbo Biosciences
Goat anti-Mouse IgG (H&L) - F(ab')2 fragment, Biotin Conjugate, min x w/bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
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Anti-IgG Goat Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
Supplier: Tonbo Biosciences
Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/bovine, human, or mouse IgG
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Anti-IgG Rabbit Polyclonal Antibody
Supplier: Tonbo Biosciences
Rabbit anti-Mouse IgG (H&L) - Affinity Pure
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Anti-IgG2b Goat Polyclonal Antibody (PE (Phycoerythrin))
Supplier: Tonbo Biosciences
Goat anti-Mouse IgG2b, secondary antibody, conjugated to SureLight® R-Phycoerythrin
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Anti-IgG Goat Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
Supplier: Tonbo Biosciences
Goat anti-Rabbit IgG (H&L), F(ab')2 Fragment - Affinity Pure, FITC Conjugate
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Anti-IgY Goat Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Tonbo Biosciences
Goat anti-Chicken IgY (H&L) - Affinity Pure, HRP Conjugate
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Anti-IgG Goat Polyclonal Antibody (PE (Phycoerythrin))
Supplier: Tonbo Biosciences
Goat anti-mouse IgG (H+L), secondary antibody, SureLight® R-Phycoerythrin, 100ug
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Anti-IgG Goat Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
Supplier: Tonbo Biosciences
Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate
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Anti-IgG Goat Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Tonbo Biosciences
Goat anti-Mouse IgG (H&L), F(ab')2 Fragment - Affinity Pure, HRP Conjugate
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Anti-IgG Donkey Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Tonbo Biosciences
Donkey anti-Goat IgG (H&L) - Affinity Pure, HRP Conjugate
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Anti-IgG Donkey Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Tonbo Biosciences
Donkey anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/mouse IgG or serum proteins
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Anti-IgG Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Tonbo Biosciences
Rabbit anti-Goat IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/human, mouse, or rat IgG
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Anti-IgG Donkey Polyclonal Antibody (Biotin)
Supplier: Tonbo Biosciences
Donkey anti-Goat IgG (H&L) - Affinity Pure, Biotin Conjugate, min x w/human, mouse, rabbit or rat IgG