Dorsomorphin ≥98% (by TLC)
Supplier: Enzo Life Sciences
Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.
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(+/-)-Anatoxin ≥98% (by TLC)
Supplier: Enzo Life Sciences
Nicotinic acetylcholine receptor ligand.
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Bisindolylmaleimide I ≥98% (by TLC)
Supplier: Enzo Life Sciences
Potent and selective protein kinase C inhibitor which has been used effectively in platelets, Swiss 3T3 fibroblasts and macrophages. Inhibitory profile: PKC, IC50=0.02µM (inhibits α, ßI, ßII and γ subtypes with similar potency); PKA, IC50=2.0µM; phosphorylase kinase, IC50=0.7µM; insulin, EGF and PDGF receptor tyrosine kinases are not inhibited at concentrations up to 50µM.
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Anti-TMC4 Rabbit Polyclonal Antibody (PE (Phycoerythrin))
Supplier: US Biological
Anti-TMC4 Rabbit Polyclonal Antibody (PE (Phycoerythrin))
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Fumagillin ≥95% (by TLC)
Supplier: Enzo Life Sciences
Methionine aminopeptidase 2 inhibitor
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H-9 HCl ≥98% (by TLC)
Supplier: Enzo Life Sciences
An excellent affinity ligand for chromatographic purification of protein kinases. Inhibits protein kinases (Ki's: PKA=1.9 µM; PKC=18 µM; PKG=0.87 µM; MLCK=70 µM).
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4-Hydroxyphenylretinamide ≥97% (by TLC)
Supplier: Enzo Life Sciences
Retinoic acid receptor ligand.
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Latrunculin A ≥98% (by TLC)
Supplier: Enzo Life Sciences
Ultra-pure; inhibits actin polymerization
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Anandamide ≥98% (by TLC)
Supplier: Enzo Life Sciences
Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].
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Palmitoylethanolamide ≥98% (by TLC)
Supplier: Enzo Life Sciences
Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.
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Ilimaquinone ≥98% (by TLC)
Supplier: Enzo Life Sciences
ADP-ribosylation factor inhibitor
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L-744,832 ≥98% (by TLC)
Supplier: Enzo Life Sciences
Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expression and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.
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BMOV ≥96% (by TLC)
Supplier: Enzo Life Sciences
Organic vanadium complex which acts as a potent insulin mimic.
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: GRANT INSTRUMENTS
: BOCHEM
: VWR Collection
: DWK Life Sciences
: Thermo Fisher Scientific
: VWR Collection
: Oxford Nanopore Technologies
: Integra
: Industrial Physics
: AAT BIOQUEST
: Integra
: Palbam
: VWR Collection
: VWR Collection
: FACELLITATE
: NANOENTEK
: Greiner Bio-One