"Stemcell Technologies"

Supplier: Stemcell Technologies

Interleukin 11 (IL-11) is a pleiotropic cytokine with effects on various tissues including the bone marrow, brain, and intestinal mucosa (Du andamp; Williams). It belongs to the IL-6 family of cytokines that share a common signal transducer, gp130. IL-11 induces the proliferation of hematopoietic stem cells (Lemoli et al.) and megakaryocytic progenitor cells (Bruno et al.), the maturation of megakaryocytes (Burstein et al.), and the production of platelets (Neben et al.). IL-11 is produced by a variety of cell types including hematopoietic cells, mesenchymal cells, epithelial cells, and neuronal cells. It was first cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102 (Kawashima et al.). The binding of IL-11 to its receptor induces heterodimerization with the gp130 subunit and activation of JAK tyrosine kinases. IL-11 was the first pharmacologic agent approved for the treatment of chemotherapy-induced thrombocytopenia. IL-11 also plays a role in cancer progression by inducing the proliferation of epithelial cancer cells and the survival of metastatic cells at distant organs. Recently, IL-11 has gained interest for its role in the pathogenesis of diseases in dysregulated mucosal homeostasis associated with STAT3 upregulation, including gastrointestinal cancers (Putoczki et al.).

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee, horse CD38, PE­conjugated.

Supplier: Stemcell Technologies

Rat monoclonal antibody against human IL-4, APC-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2a antibody against human, mouse, rat beta-tubulin III, unconjugated.

Supplier: Stemcell Technologies

Immunomagnetic isolation of untouched rat CD8+ T cells

Supplier: Stemcell Technologies

Rat monoclonal IgG2b antibody against mouse CD24, unconjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2).

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human CD45, FITC-conjugated.

Supplier: Stemcell Technologies

Hamster (Armenian) monoclonal IgG1 antibody against mouse CD3e, APC-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2b, antibody against human, chimpanzee, CD45RA, PE-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal antibody against human CD69 (AIM).

Supplier: Stemcell Technologies

For detection and measurement of human interleukin 1 beta.

Supplier: Stemcell Technologies

Immunomagnetic positive selection of particle-free human CD19+ cells.

Supplier: Stemcell Technologies

Pre-aliquoted methylcellulose-based medium with recombinant cytokines (without EPO) for human cells. 24×3 ml vials.

Supplier: Stemcell Technologies

Fluorescent lipophilic dye used to quantify mitochondrial membrane potential and assess cell viability.

Supplier: Stemcell Technologies

Immunomagnetic isolation of untouched human T cells.