"Other Essentials"

Supplier: Genscript

Efficient and gentle cell separation based on surface markers is essential for researching specific cell populations, and for developing life-saving cell and gene therapies. GenScript has renowned expertise in developing magnetic bead products for bioseparation of various types of biomolecules. The CytoSinct™ Cell Separation Technology uses perfected nanoparticle empowered immunomagnetic separation technology to isolate specific cell populations of interest, combining the specificity and sensitivity of antibody-based purification with the gentleness of nanoparticles and the ease and speed of magnetic separation.

Supplier: Portwest

This hardwearing contrast colour jacket is made of 60% cotton and 40% polyester. The soft handle cotton rich fabric is built to last and will look and feel great. Cotton ensures it washes well at 60 °C whilst the polyester gives a ruggedness essential for daily use.

Supplier: Stemcell Technologies

Hanks’ Balanced Salt Solution (HBSS) can be used for diluting, washing, irrigating or as a transporting solution for cell or tissue culture. It provides a buffering system to maintain the physiological pH range and osmotic balance of culture media, and provides cells with a source of water and essential inorganic ions and a carbohydrate as an energy source. Selection of suitable nutrient medium is dependent on type of cell, culture conditions, and degree of chemical definition required for the cell culture application.

Supplier: Stemcell Technologies

Hanks’ Balanced Salt Solution (HBSS) can be used for diluting, washing, irrigating or as a transporting solution for cell or tissue culture. It provides a buffering system to maintain the physiological pH range and osmotic balance of culture media, and provides cells with a source of water and essential inorganic ions and a carbohydrate as an energy source. Selection of suitable nutrient medium is dependent on type of cell, culture conditions, and degree of chemical definition required for the cell culture application.

Supplier: Cytiva

Capto™ HiRes Q and Capto™ HiRes S are prepacked columns for high-resolution purification of proteins and other biomolecules by ion exchange chromatography. They are well-suited for the preparation of highly pure proteins for structural studies and for protein analysis.

Supplier: Sartorius

The Sterisart® Universal pump, Gen 4 is a robust and reliable peristaltic sterility testing pump built from 316L mirror-finish stainless steel and used for sample and media transfer into the Sterisart® family of sterility testing canisters.

Supplier: Biosensis

FUNCTION: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. SUBCELLULAR LOCATION: Cytoplasm. Colocalizes with nonmuscle actin. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. INDUCTION: By apoptotic stimuli. PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane. SIMILARITY: Belongs to the ATG5 family.

Supplier: Abcam

Anti-FAK (phospho Y397 + Y576 + Y925) antibody [RM1141] is a Rabbit Recombinant Multiclonal antibody that is used in FAK (phospho Y397 + Y576 + Y925) Dot Blot, Western Blot. Suitable for Human, Mouse, Rat samples. FAK (PTK2) is a non-receptor protein-tyrosine kinase which is involved in regulation of a number of essential cellular processes, including cell cycle progression, cell migration, actic cytoskeleton organisation and formation of focal adhesions. FAK is activated by phosphorylation and recruited to focal adhesions in response to integrin signalling. Aberrant expression of FAK may play a role in tumor formation, including ovarian, breast and non-small cell lung cancers.

Supplier: Thermo Fisher Scientific

Pierce™ Recombinant Peroxidase Conjugated Protein A can be used to probe and detect rabbit and human antibodies, especially IgG isotypes, in Western blotting, ELISA, IHC and other immunoassay protocols.

Supplier: Biosensis

CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

Supplier: Cayman Chemical

TAK-242 ≥98%

Supplier: Abcam

Anti-CRBN antibody [EPR28739-64] is a Rabbit Monoclonal antibody that is used in CRBN Flow Cytometry (Intra), IP, Western Blot. Suitable for Human, Mouse samples. Cereblon (CRBN) is a multifunctional protein located in the cytoplasm, nucleus, and peripheral membranes of the human tissues. CRBN is closely related to the proliferation and metabolism of normal cells as well as tumor cells.It is part of the CRL4 CRBN ubiquitin E3 ligase complex, which is crucial for the action of immunomodulatory drugs (IMiDs) like lenalidomide and pomalidomide. These drugs bind to CRBN, leading to the degradation of transcription factors Ikaros and Aiolos, which are essential for myeloma cell survival. Additionally, novel cereblon E3 ligase modulators (CELMoDs) are being developed to overcome resistance to IMiDs, offering new therapeutic options for patients with CRBN mutation.

Supplier: BOEKEL SCIENTIFIC

RapidFISH slide hybridisation oven was designed to simplify fluorescent in-situ hybridisations procedures for FFP samples, cell suspensions, and other tissue preparation procedures.

Supplier: Cayman Chemical

S396A mutant (from E. coli)

Supplier: MP Biomedicals

Tryptone is a pancreatic digest of casein, utillised as a source of nitrogen in many culture media for growing bacteria as well as fungi.

Supplier: Merck

MVP ICON® portable hygiene monitoring system – setting a new standard.