16885 Results for: "Enzo Life Sciences"
Olomoucine ≥98%, high purity
Supplier: ENZO LIFE SCIENCES
Olomoucine is a purine derivative which acts as a potent and selective inhibitor of CDK1 (p34cdc2)/cyclin B and related kinases. It acts by competing for the ATP binding domain of the kinase. Of 35 protein kinases tested, olomoucine inhibited p33CDK2/cyclin A, p33CDK2/cyclin E, p34cdc2/cyclin B, p33CDK5/p35 and erk1 with IC50 of 7, 7, 7, 3 and 25µM respectively. The related kinases p34CDK4/cyclin D and p40CDK6/cyclin D3 were not inhibited or were less sensitive to olomoucine, IC50 > 1000 and 250µM respectively. PKC, PKA, PKG, CaM kinase II, MLC kinase, CK2, EGFR tyrosine kinase, p56lck, p56lyn, p60c-src, v-abl and insulin receptor tyrosine kinase are not inhibited or are weakly inhibited at 1mM. It delays mouse oocyte maturation and inhibits the growth of a variety of human cell lines including Rhabdomyosarcoma cell line Rh1, Rh18, Rh28 and Rh30; MCF-7, KB-3-1 and their adriamycin-resistant counterparts (IC50=18-86µM). It inhibits DNA synthesis in interleukin-2-stimulated T lymphocytes and triggers a G1 arrest similar to interleukin-2 deprivation. Can be used to synchronize cells in G1. Triggers apoptosis in target tumor cells in vitro and in vivo and in maturing cerebellar granule neurons. N9-Isopropyl-olomoucine and the negative control Iso-olomoucine are also available.
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Undeca-ubiquitin (linear)
Supplier: ENZO LIFE SCIENCES
Produced in E. coli.
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Why Choose Corning Fetal Bovine Serum?
Our vertically integrated FBS serum supply chain, from collection to scientist, allows us to provide a consistent supply of FBS.
Congo red ≥95% (by HPLC), Ultrapure
Supplier: ENZO LIFE SCIENCES
beta-Amyloid dye
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Prostaglandin D₂ ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES
Prostanoid receptor ligand.
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(+)-cis-Diltiazem hydrochloride ≥99% (by HPLC)
Supplier: ENZO LIFE SCIENCES
Inhibitor of L-type Ca²⁺ channels. Regulates Ca²⁺ release from intracellular stores in neutrophils.
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Anti-INOS Rabbit Polyclonal Antibody
Supplier: ENZO LIFE SCIENCES
Host: Rabbit, Isotype: IgG
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(+)-Himbacine ≥98%, powder
Supplier: ENZO LIFE SCIENCES
Muscarinic acetylcholine receptor antagonist.
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Spermine tetrahydrochloride
Supplier: ENZO LIFE SCIENCES
Spermine tetrahydrochloride
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PTIO (=2-phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) ≥98% (by non aqueous titration)
Supplier: ENZO LIFE SCIENCES
Stable nitric oxide (NO) radical scavenger.
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3,5,7,4'-Tetrahydroxy-3'-methoxyflavone ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES
Antitumor agent.
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4-Phenylchalcone oxide (synthetic) ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES
Potent and selective inhibitor of microsomal and cytosolic epoxide hydrolase (IC50=68 nM). Inhibits epoxide hydrolysis of epoxyeicosatrienoic acids.
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1-Acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine (ACP)
Supplier: ENZO LIFE SCIENCES
Cell permeable probe for the detection of intracellular oxidative stress.
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Src substrate II
Supplier: Enzo Life Sciences
This peptide, YIYGSFK, was derived through a random combinatorial peptide library method and is a specific and efficient substrate for the scr family of kinases. The Km of YIYGSFK for p60c-src is 55 µM.
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CDK5 substrate
Supplier: Enzo Life Sciences
This peptide, PKTPKKAKKL, is derived from histone H1 and is a substrate for CDK5.
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TG100115 ≥98% (by HPLC)
Supplier: Enzo Life Sciences
Inhibitor of PI3Kγ, PI3Kδ, FRAP, Akt and VEGF.
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Anti-Agrin Mouse Monoclonal Antibody [clone: Agr-33]
Supplier: Enzo Life Sciences
Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development.
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Anti-HSPA8 Mouse Monoclonal Antibody
Supplier: Enzo Life Sciences
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
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Anti-HSP70 Mouse Monoclonal Antibody
Supplier: Enzo Life Sciences
The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1's role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate-binding domain of Hsp70 (or Hsc70) cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.
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Mouse recombinant HSP70-A1 (from E. coli)
Supplier: Enzo Life Sciences
Produced in E. coli.
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Anti-DNAK Mouse Monoclonal Antibody [clone: 8E2/2]
Supplier: Enzo Life Sciences
DnaK possesses an autophosphorylation activity and a weak 5-nucleotidase activity, cleaving the 5 phosphate groups from both ribose and deoxyribose nucleotides. The role of DnaK in ATP-dependent protein-protein interactions has been extended to normal E. coli physiology, where, like eukaryotic Hsp70 homologs, it is thought to participate in the assembly/disassembly of protein complexes.
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Rat recombinant HSP60 (from E. coli)
Supplier: Enzo Life Sciences
Produced in E. coli.
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: EPPENDORF
: Integra
: OZ BIOSCIENCES
: VWR Collection
: SenseAnywhere
: Integra
: NANOENTEK
: VWR Collection
: Integra
: Sartorius
: Quantabio