CF® Dyes, Methotrexate Conjugates

Cytotoxic agent that binds and inhibits dihydrofolate reductase. Useful for studying antimetabolite resistance, spontaneous gene amplification, and drug binding. Available conjugated to fluorescein and CF® Dyes.

Methotrexate is a cytotoxic agent used as a chemotherapeutic and immunosuppressant. It is actively taken up by cells and binds to and inhibits dihydrofolate reductase, thereby inhibiting folic acid metabolism and inducing cell cycle arrest. Methotrexate fluorescein is useful for studying antimetabolite resistance and spontaneous gene amplification. Other dye conjugates of methotrexate may not be transported into cells, but may have other applications for studies of drug binding.

Offers methotrexate conjugated to fluorescein and a selection of our next-generation fluorescent CF® Dyes.

CF® Dyes were designed to be highly water-soluble with advantages in brightness and photostability compared to other commercially available fluorescent dyes.