CpG methyltransferase enzyme methylates the C5 position on the base moiety of all cytosine nucleotides contained in unmethylated or hemimethylated double stranded DNA in a 5'-CpG-3' context. Thermo Scientific M.SssI is specifically formulated for fast reaction times without compromising the reaction efficiency. The enzyme completes modification of all CpGs in 15 minutes at 37 °C. In addition, the enzyme has been specifically validated for use with genomic DNA – the primary substrate in epigenetic studies.

• High efficiency: Complete in vitro methylation of all CpGs in non-methylated and hemi-methylated DNA
• Fast: Reaction is completed in 15 minutes at 37 °C
• Stable at −20 °C for up to 2 years