Anti-IL-2 Mouse Monoclonal Antibody [clone: MT8G10] (Biotin)

STMC100-1465

: STEMCELL Technologies

New Product

Anti-IL-2 Mouse Monoclonal Antibody [clone: MT8G10] (Biotin)

STMC100-1465

: STEMCELL Technologies

New Product

Antigen name:
IL-2
Clonality:
Monoclonal
Clone:
MT8G10
Conjugation:
Biotin
Host:
Mouse
Isotype:
IgG1
Reactivity:
Other,
Human
Gene ID:
3558
Pk:
250 µG

Mouse monoclonal antibody against human, cynomolgus IL-2.

Nk cells
T cells CD4
T cells CD8

This mouse monoclonal antibody (clone MT8G10) reacts with human interleukin 2 (IL-2). IL-2 is an ~16 kDa cytokine composed of a four-alpha-helix bundle (Arenas-Ramirez et al.), produced primarily by CD4+ T helper (Th) cells and to a lesser degree by CD8+ T cells, natural killer (NK) cells, and NK T cells (Boyman & Sprent). It binds to the IL-2 receptor α (IL-2Rα; CD25), which complexes with IL-2Rꞵ (CD122) and γc (CD132) subunits (Malek & Castro) and leads to the activation of JAK1/3, P13K-AKT, and MAPK signaling pathways (Arenas-Ramirez et al.). IL-2 mediates T cell growth and proliferation, facilitates the differentiation of CD4+ T cells to Th1 and Th2 cells, promotes CD8+ T cell and NK cell cytolytic activity, and drives the development of CD4+FOXP3+ regulatory T cells (Liao et al.).

: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: IL-2
Clonality: Monoclonal
Clone: MT8G10
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Other