FH535 ≥98% (by TLC)

Inhibits the recruitment of the co-activators β-catenin and GRIP1

Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways. FH535 was toxic (LC50=5 to 15µM) to 10 of 12 carcinoma cell lines tested. A unique tool to study the relationship between Wnt and PPAR signaling pathways.