MC192-saporin is an antibody conjugate comprising of the monoclonal antibody MC192 against rat p75NTR, the nerve growth factor receptor, chemically conjugated via a reducible disulfide bridge to the ribosome-inactivating protein saporin, purified from saponaria officinalis.

• Specific only for rat NGFR
• No reactivity to human or mouse NGFR has been reported
• Does not cross react with p75NTR-expressing cells in other species than rat

Unconjugated saporin is incapable of entering the cells due to the apparent lack of ligand. Upon specific binding via MC192 to the cells expressing p75NTR, saporin transverses the cell membrane leading to lesion of neurochemically defined neuronal populations. The targets of MC192-Saporin are p75NTR-expressing cells including cholinergic neurons of the basal forebrain, cerebellar Purkinje cells, medial septum, diagonal band of broca, nucleus basalis of Meynert and some tumor cells. MC192-saporin has been used in the study of learning and memory and its primary application is in vivo, MC192-saporin is specific for applications in rat. The antibody does not cross-react with human or mouse p75NTR receptors.

Other application: A model for gene delivery into neurons.

Type: Primary
Antigen: NGFR
Clonality: Monoclonal
Clone: MC192
Conjugation: Saporin
Epitope: Extracellular
Host: Mouse
Isotype: IgG1
Reactivity: Rat